{"created":"2023-05-15T14:37:23.550316+00:00","id":48221,"links":{},"metadata":{"_buckets":{"deposit":"6491679c-fbd1-4ce2-9a1c-80d78343d0b3"},"_deposit":{"created_by":1,"id":"48221","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48221"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048221","sets":["1"]},"author_link":["484466","484463","484460","484464","484459","484462","484461","484465"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"2403","bibliographicPageStart":"2397","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"Nano letters"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this study we describe the construction of a system composed of thermally responsive molecules that can be induced to accumulate in tumor tissues by heating. EgX molecules consisting of an urea-benzene framework and oligoethylene glycol (OEG) functional groups with an emissive aminoquinoline formed nanoparticles (NPs) ∼10 nm in size at 23 °C with a fluorescence quantum yield of 7-10%. At higher temperatures, additional self-assembly occurred as a result of OEG dehydration, and the NPs grew to over 1000 nm in size; this was accompanied by low critical solution temperature behavior. EgXs accumulated in tumor tissues of mice at a body temperature of around 33-35 °C, an effect that was accelerated by external heating around the tumor to approximately 40 °C as a result of increased particle size and enhanced retention in tissue. These EgX NPs can serve as a tool for in vivo monitoring of tumor progression and response to treatment.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"28264561","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1021/acs.nanolett.6b05371","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1530-6984","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Araki, Takeru"}],"nameIdentifiers":[{"nameIdentifier":"484459","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murayama, Shuhei"}],"nameIdentifiers":[{"nameIdentifier":"484460","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Usui, Kazuteru"}],"nameIdentifiers":[{"nameIdentifier":"484461","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"484462","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"484463","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Karasawa, Satoru"}],"nameIdentifiers":[{"nameIdentifier":"484464","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村山 周平","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"484465","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"484466","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Self-Assembly Behavior of Emissive Urea Benzene Derivatives Enables Heat-Induced Accumulation in Tumor Tissue.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Self-Assembly Behavior of Emissive Urea Benzene Derivatives Enables Heat-Induced Accumulation in Tumor Tissue."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-07-27"},"publish_date":"2017-07-27","publish_status":"0","recid":"48221","relation_version_is_last":true,"title":["Self-Assembly Behavior of Emissive Urea Benzene Derivatives Enables Heat-Induced Accumulation in Tumor Tissue."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:30:33.264930+00:00"}