@article{oai:repo.qst.go.jp:00048221,
 author = {Araki, Takeru and Murayama, Shuhei and Usui, Kazuteru and Shimada, Takashi and Aoki, Ichio and Karasawa, Satoru and 村山 周平 and 青木 伊知男},
 issue = {4},
 journal = {Nano letters},
 month = {Mar},
 note = {In this study we describe the construction of a system composed of thermally responsive molecules that can be induced to accumulate in tumor tissues by heating. EgX molecules consisting of an urea-benzene framework and oligoethylene glycol (OEG) functional groups with an emissive aminoquinoline formed nanoparticles (NPs) ∼10 nm in size at 23 °C with a fluorescence quantum yield of 7-10%. At higher temperatures, additional self-assembly occurred as a result of OEG dehydration, and the NPs grew to over 1000 nm in size; this was accompanied by low critical solution temperature behavior. EgXs accumulated in tumor tissues of mice at a body temperature of around 33-35 °C, an effect that was accelerated by external heating around the tumor to approximately 40 °C as a result of increased particle size and enhanced retention in tissue. These EgX NPs can serve as a tool for in vivo monitoring of tumor progression and response to treatment.},
 pages = {2397--2403},
 title = {Self-Assembly Behavior of Emissive Urea Benzene Derivatives Enables Heat-Induced Accumulation in Tumor Tissue.},
 volume = {17},
 year = {2017}
}