{"created":"2023-05-15T14:37:21.906338+00:00","id":48184,"links":{},"metadata":{"_buckets":{"deposit":"38b230ac-41f9-4064-af46-0ed0fd5641e5"},"_deposit":{"created_by":1,"id":"48184","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48184"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048184","sets":["1"]},"author_link":["484003","483994","483993","484002","484000","483998","484004","483996","484001","483999","483997","483995"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"130","bibliographicPageStart":"116","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Developmental cell"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Autophagy is a cytoplasmic degradation system that is important for starvation adaptation and cellular quality control. Previously, we reported that Atg5-null mice are neonatal lethal; however, the exact cause of their death remains unknown. Here, we show that restoration of ATG5 in the brain is sufficient to rescue Atg5-null mice from neonatal lethality. This suggests that neuronal dysfunction, including suckling failure, is the primary cause of the death of Atg5-null neonates, which would further be accelerated by nutrient insufficiency due to a systemic failure in autophagy. The rescued Atg5-null mouse model, as a resource, allows us to investigate the physiological roles of autophagy in the whole body after the neonatal period. These rescued mice demonstrate previously unappreciated abnormalities such as hypogonadism and iron-deficiency anemia. These observations provide new insights into the physiological roles of the autophagy factor ATG5.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Cell Press"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"27693508","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.devcel.2016.09.001","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1534-5807","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"R, Yoshii Saori"}],"nameIdentifiers":[{"nameIdentifier":"483993","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuma, Akiko"}],"nameIdentifiers":[{"nameIdentifier":"483994","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Akashi, Takumi"}],"nameIdentifiers":[{"nameIdentifier":"483995","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hara, Taichi"}],"nameIdentifiers":[{"nameIdentifier":"483996","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"483997","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurikawa, Yoshitaka"}],"nameIdentifiers":[{"nameIdentifier":"483998","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Itakura, Eisuke"}],"nameIdentifiers":[{"nameIdentifier":"483999","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsukamoto, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"484000","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shitara, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"484001","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Eishi, Yoshinobu"}],"nameIdentifiers":[{"nameIdentifier":"484002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizushima, Noboru"}],"nameIdentifiers":[{"nameIdentifier":"484003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"塚本 智史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"484004","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-07-25"},"publish_date":"2017-07-25","publish_status":"0","recid":"48184","relation_version_is_last":true,"title":["Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:30:59.665601+00:00"}