{"created":"2023-05-15T14:37:21.335910+00:00","id":48171,"links":{},"metadata":{"_buckets":{"deposit":"726b8d6d-a845-48d5-b325-88f80647fa11"},"_deposit":{"created_by":1,"id":"48171","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48171"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048171","sets":["1"]},"author_link":["483848","483841","483845","483842","483846","483847","483839","483840","483844","483849","483843"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"2069","bibliographicPageStart":"2055","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"Physics in Medicine and Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Silicon microdosimetry is a promising technology for heavy ion therapy (HIT)\nquality assurance, because of its sub-mm spatial resolution and capability to\ndetermine radiation effects at a cellular level in a mixed radiation field. A\ndrawback of silicon is not being tissue-equivalent, thus the need to convert the\ndetector response obtained in silicon to tissue. This paper presents a method\nfor converting silicon microdosimetric spectra to tissue for a therapeutic 12C\nbeam, based on Monte Carlo simulations. The energy deposition spectra in\na 10 μm sized silicon cylindrical sensitive volume (SV) were found to be\nequivalent to those measured in a tissue SV, with the same shape, but with\ndimensions scaled by a factor κ equal to 0.57 and 0.54 for muscle and water,\nrespectively. A low energy correction factor was determined to account for\nthe enhanced response in silicon at low energy depositions, produced by\nelectrons. The concept of the mean path length lPath to calculate the lineal\nenergy was introduced as an alternative to the mean chord length l because\nit was found that adopting Cauchy’s formula for the l was not appropriate\nfor the radiation field typical of HIT as it is very directional. lPath can be\ndetermined based on the peak of the lineal energy distribution produced by\nthe incident carbon beam. Furthermore it was demonstrated that the thickness\nof the SV along the direction of the incident 12C ion beam can be adopted\nas lPath . The tissue equivalence conversion method and lPath were adopted\nto determine the RBE10, calculated using a modified microdosimetric kinetic\nmodel, applied to the microdosimetric spectra resulting from the simulation\nstudy. Comparison of the RBE10 along the Bragg peak to experimental TEPC measurements at HIMAC, NIRS, showed good agreement. Such agreement demonstrates the validity of the developed tissue equivalence correction\nfactors and of the determination of lPath .","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"IOP Publishing"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1088/1361-6560/aa5de5","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1120-1797","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ＢＯＬＳＴ, Ｄａｖｉｄ"}],"nameIdentifiers":[{"nameIdentifier":"483839","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"guatelli, susanna"}],"nameIdentifiers":[{"nameIdentifier":"483840","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｔｒａｎ, Ｔｈｕｙ Ｌｉｎｈ"}],"nameIdentifiers":[{"nameIdentifier":"483841","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｃｈａｒｔｉｅｒ, Ｌａｃｈｌａｎ"}],"nameIdentifiers":[{"nameIdentifier":"483842","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lerch, Michael"}],"nameIdentifiers":[{"nameIdentifier":"483843","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松藤, 成弘"}],"nameIdentifiers":[{"nameIdentifier":"483844","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Rosenfeld, Anatoly"}],"nameIdentifiers":[{"nameIdentifier":"483845","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ＢＯＬＳＴ Ｄａｖｉｄ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"483846","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｔｒａｎ Ｔｈｕｙ Ｌｉｎｈ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"483847","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｃｈａｒｔｉｅｒ Ｌａｃｈｌａｎ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"483848","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松藤 成弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"483849","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Correction factors to convert microdosimetry measurements in silicon to tissue in 12C ion therapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Correction factors to convert microdosimetry measurements in silicon to tissue in 12C ion therapy"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-07-24"},"publish_date":"2017-07-24","publish_status":"0","recid":"48171","relation_version_is_last":true,"title":["Correction factors to convert microdosimetry measurements in silicon to tissue in 12C ion therapy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:31:07.290721+00:00"}