{"created":"2023-05-15T14:37:20.771273+00:00","id":48158,"links":{},"metadata":{"_buckets":{"deposit":"57254f90-90d2-46b3-a2d5-cbfd71f35338"},"_deposit":{"created_by":1,"id":"48158","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48158"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048158","sets":["1"]},"author_link":["483641","483636","483640","483639","483637","483642","483638"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"335","bibliographicPageStart":"325","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Both psychological stress (PS) and ionizing radiation (IR) cause varied detrimental effects on humans. There\nhas been no direct evidence so far showing PS alone could cause cancer; however, long-lasting PS may affect\nour overall health and ability to cope with cancer. Due to their living conditions and occupations, some people\nmay encounter concurrent exposure to both PS and IR to a high extent. In addition to possible health effects\nresulting directly from exposure to IR on these people, fear of IR exposure is also a cause of PS. The question of\nwhether PS would influence susceptibility to IR, radiocarcinogenesis in particular, is of great concern by both\nthe academic world and the public. Recently, investigations using animal PS models demonstrated that PS could\nmodulate susceptibility to IR, causing increased susceptibility to radiocarcinogenesis in Trp53-heterozygous\nmice, hematological toxicity in peripheral blood and elevated chromosome aberration (dicentrics) frequency in\nsplenocytes of Trp53–wild-type mice. To actively reduce health risk from exposure to IR, further studies are\nneeded to cumulate more evidence and provide insights into the mechanisms underlying the alterations in susceptibility\ndue to PS modulation. This mini-review gives a general overview of the significance of PS effects on\nhumans and experimental animals, with a special focus on summarizing the latest weight-of-evidence approaches\nto radiobiological studies on PS-induced alterations in susceptibility in experimental animal models. The susceptibility\nbeing investigated is mainly in the context of the impact of the modulatory effect of PS on radiocarcinogenesis;\nwe seek to improve understanding of the combined effects of exposure to both PS and IR in order to\nfacilitate, via active intervention, strategies for radiation risk reduction.\nKEYWORDS: psychological stress, ionizing radiation, radiosusceptibility, radiocarcinogenesis, mouse psychological\nstress model","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford Journals, Oxford University Press"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1093/jrr/rrw035","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://academic.oup.com/jrr/article-lookup/doi/10.1093/jrr/rrw035"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://academic.oup.com/jrr/article-lookup/doi/10.1093/jrr/rrw035","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0449-3060","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wang, Bing"}],"nameIdentifiers":[{"nameIdentifier":"483636","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katsube, Takanori"}],"nameIdentifiers":[{"nameIdentifier":"483637","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Begum, Nasrin"}],"nameIdentifiers":[{"nameIdentifier":"483638","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nenoi, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"483639","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"483640","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"勝部 孝則","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"483641","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"483642","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Revisiting the health effects of psychological stress—its influence on susceptibility to ionizing radiation: a mini-review","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Revisiting the health effects of psychological stress—its influence on susceptibility to ionizing radiation: a mini-review"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-07-24"},"publish_date":"2017-07-24","publish_status":"0","recid":"48158","relation_version_is_last":true,"title":["Revisiting the health effects of psychological stress—its influence on susceptibility to ionizing radiation: a mini-review"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:31:16.704980+00:00"}