@article{oai:repo.qst.go.jp:00048158,
 author = {Wang, Bing and Katsube, Takanori and Begum, Nasrin and Nenoi, Mitsuru and 王 冰 and 勝部 孝則 and 根井 充},
 issue = {4},
 journal = {Journal of Radiation Research},
 month = {Jul},
 note = {Both psychological stress (PS) and ionizing radiation (IR) cause varied detrimental effects on humans. There
has been no direct evidence so far showing PS alone could cause cancer; however, long-lasting PS may affect
our overall health and ability to cope with cancer. Due to their living conditions and occupations, some people
may encounter concurrent exposure to both PS and IR to a high extent. In addition to possible health effects
resulting directly from exposure to IR on these people, fear of IR exposure is also a cause of PS. The question of
whether PS would influence susceptibility to IR, radiocarcinogenesis in particular, is of great concern by both
the academic world and the public. Recently, investigations using animal PS models demonstrated that PS could
modulate susceptibility to IR, causing increased susceptibility to radiocarcinogenesis in Trp53-heterozygous
mice, hematological toxicity in peripheral blood and elevated chromosome aberration (dicentrics) frequency in
splenocytes of Trp53–wild-type mice. To actively reduce health risk from exposure to IR, further studies are
needed to cumulate more evidence and provide insights into the mechanisms underlying the alterations in susceptibility
due to PS modulation. This mini-review gives a general overview of the significance of PS effects on
humans and experimental animals, with a special focus on summarizing the latest weight-of-evidence approaches
to radiobiological studies on PS-induced alterations in susceptibility in experimental animal models. The susceptibility
being investigated is mainly in the context of the impact of the modulatory effect of PS on radiocarcinogenesis;
we seek to improve understanding of the combined effects of exposure to both PS and IR in order to
facilitate, via active intervention, strategies for radiation risk reduction.
KEYWORDS: psychological stress, ionizing radiation, radiosusceptibility, radiocarcinogenesis, mouse psychological
stress model},
 pages = {325--335},
 title = {Revisiting the health effects of psychological stress—its influence on susceptibility to ionizing radiation: a mini-review},
 volume = {57},
 year = {2016}
}