{"created":"2023-05-15T14:37:17.592322+00:00","id":48085,"links":{},"metadata":{"_buckets":{"deposit":"6367f439-011f-41f1-ae80-cb8b7e84b90e"},"_deposit":{"created_by":1,"id":"48085","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48085"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048085","sets":["1"]},"author_link":["482815","482819","482814","482816","482823","482821","482818","482820","482825","482822","482817","482812","482824","482813"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"29","bibliographicPageEnd":"17979","bibliographicPageStart":"17968","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"RSC Advances"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Three quercetin derivatives with enhanced radical-scavenging activity were designed and synthesised.  Because the radical-scavenging reaction of quercetin is known to proceed via an electron transfer from quercetin to radicals, producing the corresponding quercetin radical cation intermediate, the introduction of electron-donating groups into the quercetin molecule is expected to enhance its radical-scavenging activity.  Thus, methyl groups were introduced into the catechol moiety in the quercetin molecule at either the 2'- or 5'-position, or both.  All three quercetin analogues were found to exhibit higher radical-scavenging activity than the parent quercetin.  The activity of 5'-methylquercetin is the highest among the three analogues.  The optimised structure of 5'-methylquercetin calculated by density functional theory demonstrated a coplanar structure between the 4H-curomen (AC rings) and catechol (B ring) moieties, while dimethylquercetin and 2'-methylquercetin have a twisted structure between the Ac and B rings.  These results demonstrate that the highest radical-scavenging activity of 5'-methylquercetin is due to the stabiisation of the radical cation intermediate by the electron-donating effect of the methyl group as well as by the planar structure of the molecule. ","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Royal Society of Chemistry"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1039/C7RA02329D","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2046-2069","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Imai, Kohei"}],"nameIdentifiers":[{"nameIdentifier":"482812","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakanishi, Ikuo"}],"nameIdentifiers":[{"nameIdentifier":"482813","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohkubo, Kei"}],"nameIdentifiers":[{"nameIdentifier":"482814","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohba, Yusuke"}],"nameIdentifiers":[{"nameIdentifier":"482815","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arai, Takuya"}],"nameIdentifiers":[{"nameIdentifier":"482816","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizuno, Mirei"}],"nameIdentifiers":[{"nameIdentifier":"482817","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukuzumi, Shunichi"}],"nameIdentifiers":[{"nameIdentifier":"482818","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Kenichiro"}],"nameIdentifiers":[{"nameIdentifier":"482819","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukuhara, Kiyoshi"}],"nameIdentifiers":[{"nameIdentifier":"482820","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 耕平","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"482821","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中西 郁夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"482822","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大久保 敬","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"482823","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒井 卓也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"482824","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 謙一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"482825","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Synthesis of Methylated Quercetin Analogues for Enhancement of Radical-Scavenging Activity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Synthesis of Methylated Quercetin Analogues for Enhancement of Radical-Scavenging Activity"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-07-12"},"publish_date":"2017-07-12","publish_status":"0","recid":"48085","relation_version_is_last":true,"title":["Synthesis of Methylated Quercetin Analogues for Enhancement of Radical-Scavenging Activity"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:32:09.508142+00:00"}