@article{oai:repo.qst.go.jp:00048069,
 author = {Kumata, Katsushi and Yamasaki, Tomoteru and Hatori, Akiko and Zhang, Yiding and Mori, Wakana and Fujinaga, Masayuki and Xie, Lin and Ohkubo, Takayuki and Nengaki, Nobuki and Zhang, Ming-Rong and 熊田 勝志 and 山崎 友照 and 羽鳥 晶子 and 張 一鼎 and 森 若菜 and 藤永 雅之 and 謝 琳 and 大久保 崇之 and 念垣 信樹 and 張 明栄},
 issue = {14},
 journal = {Bioorganic & Medicinal Chemistry Letters},
 month = {May},
 note = {The purpose of this study was to develop three new radiotracers, 1-(cyclopropylmethyl)-4-([11C/18F]substituted-phenyl)piperidin-1-yl-2-oxo-1,2-dihydropyridine-3-carbonitrile ([11C]1, [11C]2, and [18F]4), and to examine their specific bindings with metabotropic glutamate receptor subtype 2 (mGluR2) in rat brain sections by using in vitro autoradiography. These compounds were found to possess potent in vitro binding affinities (Ki: 8.0-34.1nM) for mGluR2 in rat brain homogenate. [11C]1, [11C]2, and [18F]4 were synthesized by [11C/18F]alkylation of the corresponding phenol precursors with [11C]methyl iodide or [18F]fluoroethyl bromide with >98% radiochemical purity and 80-130GBq/μmol specific activity at the end of synthesis. In vitro autoradiography indicated that these radiotracers showed heterogeneous specific bindings in mGluR2-rich brain regions, such as the cerebral cortex, striatum, hippocampus, and granular layer of the cerebellum.},
 pages = {3139--3143},
 title = {Synthesis and In Vitro Evaluation of Three Novel Radiotracers for Imaging of Metabotropic Glutamate Receptor Subtype 2 in Rat Brain},
 volume = {27},
 year = {2017}
}