@article{oai:repo.qst.go.jp:00047944,
 author = {Nagata, Kento and Hashimoto, Chika and Watanabe-Asaka, Tomomi and Itoh, Kazusa and Yasuda, Takako and Oonishi, Hisako and Ohta, Kousaku and Igarashi, Kento and Suzuki, Michiyo and Funayama, Tomoo and Kobayashi, Yasuhiko and Nishimaki, Toshiyuki and Katsumura, Takafumi and Oota, Hiroki and Ogawa, Motoyuki and Oga, Atsunori and Ikemoto, Kenzo and Itoh, Hiroshi and Kutsuna, Natsumaro and Oda, Shoji and Mitani, Hiroshi and 鈴木 芳代 and 舟山 知夫 and 小林 泰彦},
 journal = {Scientific Reports},
 month = {Jun},
 note = {Radiotherapy is widely used in cancer treatment. In addition to inducing effects in the irradiated area, irradiation may induce effects on tissues close to and distant from the irradiated area. Japanese medaka, Oryzias latipes, is a small teleost fish and a model organism for evaluating the environmental effects of radiation. In this study, we applied low-energy carbon-ion (26.7 MeV/u) irradiation to adult medaka to a depth of approximately 2.2 mm from the body surface using an irradiation system at the National Institutes for Quantum and Radiological Science and Technology. We histologically evaluated the systemic alterations induced by irradiation using serial sections of the whole body, and conducted a heart rate analysis. Tissues from the irradiated side showed signs of serious injury that corresponded with the radiation dose. A 3D reconstruction analysis of the kidney sections showed reductions in the kidney volume and blood cell mass along the irradiated area, reflecting the precise localization of the injuries caused by carbon-beam irradiation. Capillary aneurysms were observed in the gill in both ventrally and dorsally irradiated fish, suggesting systemic irradiation effects. The present study provides an in vivo model for further investigation of the effects of irradiation beyond the locally irradiated area.},
 pages = {28691-1--28691-9},
 title = {In vivo 3D analysis of systemic effects after local heavy-ion beam irradiation in an animal model},
 volume = {6},
 year = {2016}
}