{"created":"2023-05-15T14:37:10.265598+00:00","id":47916,"links":{},"metadata":{"_buckets":{"deposit":"6f08bdd1-15fc-45a5-b7f3-cef5556e7e93"},"_deposit":{"created_by":1,"id":"47916","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47916"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047916","sets":["1"]},"author_link":["481051","481054","481050","481056","481055","481052","481053","481057"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-04","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"11254-12","bibliographicPageStart":"11254-1","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Nature Communications  (Online Only URL:http://www.nature.com/ncomms/index.html)"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Although autism spectrum disorder (ASD) is a serious lifelong condition, its underlying neural mechanism remains unclear. Recently, neuroimaging-based classifiers for ASD and typically developed (TD) individuals were developed to identify the abnormality of functional connections (FCs). Due to over-fitting and interferential effects of varying measurement conditions and demographic distributions, no classifiers have been strictly validated for independent cohorts. Here we overcome these difficulties by developing a novel machine- learning algorithm that identifies a small number of FCs that separates ASD versus TD. The classifier achieves high accuracy for a Japanese discovery cohort and demonstrates a remarkable degree of generalization for two independent validation cohorts in the USA and Japan. The developed ASD classifier does not distinguish individuals with major depressive disorder and attention-deficit hyperactivity disorder from their controls but moderately distinguishes patients with schizophrenia from their controls. The results leave open the viable possibility of exploring neuroimaging-based dimensions quantifying the multiple-disorder spectrum.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"27075704","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/ncomms11254","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"www.nature.com/nature communications"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"www.nature.com/nature communications","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2041-1723","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yahata, Noriaki"}],"nameIdentifiers":[{"nameIdentifier":"481050","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morimoto, Jun"}],"nameIdentifiers":[{"nameIdentifier":"481051","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hashimoto, Ryuichiro"}],"nameIdentifiers":[{"nameIdentifier":"481052","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lisi, Giuseppe"}],"nameIdentifiers":[{"nameIdentifier":"481053","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibata, Kazuhisa"}],"nameIdentifiers":[{"nameIdentifier":"481054","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawato, Mitsuo"}],"nameIdentifiers":[{"nameIdentifier":"481055","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"481056","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"八幡 憲明","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"481057","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A small number of abnormal brain connections predicts adult autism spectrum disorder","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A small number of abnormal brain connections predicts adult autism spectrum disorder"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-01"},"publish_date":"2017-05-01","publish_status":"0","recid":"47916","relation_version_is_last":true,"title":["A small number of abnormal brain connections predicts adult autism spectrum disorder"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:34:06.662752+00:00"}