{"created":"2023-05-15T14:37:10.135747+00:00","id":47913,"links":{},"metadata":{"_buckets":{"deposit":"1a1057fe-d91a-4768-a68d-6607d7a28716"},"_deposit":{"created_by":1,"id":"47913","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47913"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047913","sets":["1"]},"author_link":["481005","481003","481002","481008","481001","481014","481015","481006","481016","481018","481019","481009","481012","481013","481011","481017","481010","481004","481007"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"500","bibliographicPageStart":"492","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"Environmental Health and Preventive Medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Studies have shown that inhaled mine dust, such as asbestos, can be translocated to various organs including the lymph nodes. Recently, we have established a protocol that enables us to identify inhaled elements using paraffin embedded lung specimens by in-air microparticle-induced X-ray emission (micro-PIXE). However, little research has examined the concentration of these inhaled fibers in various organs or the mechanisms of their translocation. In this study, we compared the concentration of inhaled fibers in the lung parenchyma to the concentration in the hilar lymph node as well as to determine the elemental spatial distribution of the inhaled fibers in a patient with occupational asbestos exposure.\nLung tissues and hilar lymph node in a patient with asbestos exposure were used in this study. Elemental analysis was performed by in-air micro-PIXE. Immunohistochemical analysis was performed using anti CD163, smooth muscle actin, vimentin and β-catenin antibody.\nThe analysis revealed that the amount of inhaled silicon was approximately 6 times higher in the lymph node than in the lungs. The spatial analysis showed that silicon, iron and aluminium were co-localized in the hilar lymph node. The immunohistochemical analysis showed localized agreement of the inhaled fibers with macrophages, smooth muscle actin, and vimentin in the hilar lymph node.\nThis study showed that in-air micro-PIXE could be useful for analyzing the elemental distribution and quantification of inhaled fibers in the human body. Furthermore, immunohistochemistry in combination with in-air micro-PIXE analyses may help to determine the mechanism of mine dust distribution in vivo.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer International Publishing AG."}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s12199-016-0576-5","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.1007/s12199-016-0576-5"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s12199-016-0576-5","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1342-078X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Koga, Yasuhiko"}],"nameIdentifiers":[{"nameIdentifier":"481001","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Satoh, Takahiro"}],"nameIdentifiers":[{"nameIdentifier":"481002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kaira, Kyoichi"}],"nameIdentifiers":[{"nameIdentifier":"481003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koka, Masashi"}],"nameIdentifiers":[{"nameIdentifier":"481004","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hisada, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"481005","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirato, Junko"}],"nameIdentifiers":[{"nameIdentifier":"481006","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Altan, Bolag"}],"nameIdentifiers":[{"nameIdentifier":"481007","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yatomi, Masakiyo"}],"nameIdentifiers":[{"nameIdentifier":"481008","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Akihiro"}],"nameIdentifiers":[{"nameIdentifier":"481009","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamide, Yosuke"}],"nameIdentifiers":[{"nameIdentifier":"481010","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimizu, Yasuo"}],"nameIdentifiers":[{"nameIdentifier":"481011","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki-Saito, Haruka"}],"nameIdentifiers":[{"nameIdentifier":"481012","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsurumaki, Hiroaki"}],"nameIdentifiers":[{"nameIdentifier":"481013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimizu, Kimihiro"}],"nameIdentifiers":[{"nameIdentifier":"481014","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mogi, Akira"}],"nameIdentifiers":[{"nameIdentifier":"481015","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishizuka, Tamotsu"}],"nameIdentifiers":[{"nameIdentifier":"481016","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Masanobu"}],"nameIdentifiers":[{"nameIdentifier":"481017","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Dobashi, Kunio"}],"nameIdentifiers":[{"nameIdentifier":"481018","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤 隆博","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"481019","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Elemental and immunohistochemical analysis of the lungs and hilar lymph node in a patient with asbestos exposure, a pilot study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Elemental and immunohistochemical analysis of the lungs and hilar lymph node in a patient with asbestos exposure, a pilot study"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-01"},"publish_date":"2017-05-01","publish_status":"0","recid":"47913","relation_version_is_last":true,"title":["Elemental and immunohistochemical analysis of the lungs and hilar lymph node in a patient with asbestos exposure, a pilot study"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:34:08.807978+00:00"}