@article{oai:repo.qst.go.jp:00047817,
 author = {Gopalan, Venkatesh and Michael, Navin and Ishino, Seigo and Shean, Lee Swee and Yating, Yang Adonsia and N, Bhanu Prakash K and Yaligar, Jadegoud and Anand, Sadananthan Suresh and Kaneko, Manami and Zhou, Zhihong and Satomi, Yoshinori and Hirayama, Megumi and Kamiguchi, Hidenori and Zhu, Bin and Horiguchi, Takashi and Nishimoto, Tomoyuki and Sendhil, Velan S and 堀口 隆司},
 journal = {Scientific reports},
 month = {May},
 note = {Both exercise and calorie restriction interventions have been recommended for inducing weight-loss in obese states. However, there is conflicting evidence on their relative benefits for metabolic health and insulin sensitivity. This study seeks to evaluate the differential effects of the two interventions on fat mobilization, fat metabolism, and insulin sensitivity in diet-induced obese animal models. After 4 months of ad libitum high fat diet feeding, 35 male Fischer F344 rats were grouped (n = 7 per cohort) into sedentary control (CON), exercise once a day (EX1), exercise twice a day (EX2), 15% calorie restriction (CR1) and 30% calorie restriction (CR2) cohorts. Interventions were carried out over a 4-week period. We found elevated hepatic and muscle long chain acylcarnitines with both exercise and calorie restriction, and a positive association between hepatic long chain acylcarnitines and insulin sensitivity in the pooled cohort. Our result suggests that long chain acylcarnitines may not indicate incomplete fat oxidation in weight loss interventions. Calorie restriction was found to be more effective than exercise in reducing body weight. Exercise, on the other hand, was more effective in reducing adipose depots and muscle triglycerides, favorably altering muscle/liver desaturase activity and improving insulin sensitivity.},
 pages = {26445-1--26445-10},
 title = {Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats.},
 volume = {6},
 year = {2016}
}