{"created":"2023-05-15T14:37:04.208907+00:00","id":47777,"links":{},"metadata":{"_buckets":{"deposit":"a89cc20d-4159-4c84-b01f-2858298b09f1"},"_deposit":{"created_by":1,"id":"47777","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47777"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047777","sets":["1"]},"author_link":["479494","479508","479505","479490","479495","479518","479491","479509","479493","479512","479499","479497","479489","479516","479492","479498","479511","479515","479500","479507","479506","479514","479517","479513","479501","479488","479496","479510","479503","479504","479502","479519"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"45","bibliographicPageEnd":"11558","bibliographicPageStart":"11544","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"The Journal of neuroscience : the official journal of the Society for Neuroscience"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Chemogenetic manipulation of neuronal activities has been enabled by a designer receptor (DREADD) exclusively activated by clozapine-N-oxide (CNO). Here, we applied CNO as a functional reporter probe to positron emission tomography (PET) of DREADD in living brains. Mutant human M4 DREADD (hM4Di) expressed in transgenic mouse neurons was visualized by PET with microdose [11C]CNO. Deactivation of DREADD-expressing neurons in these mice by nonradioactive CNO at a pharmacological dose could also be captured by arterial spin labeling MRI (ASL-MRI). Neuroprogenitors derived from hM4Di transgenic-induced pluripotent stem cells (iPSCs) were then implanted into wild-type mouse brains, and neuronal differentiation of the grafts could be imaged by [11C]CNO-PET. Finally, ASL-MRI captured chemogenetic functional manipulation of the graft neurons. Our data provide the first demonstration of multimodal molecular/functional imaging of cells expressing a functional gene reporter in the brain, which would be translatable to humans for therapeutic gene transfers and cell replacements.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society for Neuroscience"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"27911758","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1523/JNEUROSCI.1279-16.2016","subitem_relation_type_select":"DOI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"JI, BIN"}],"nameIdentifiers":[{"nameIdentifier":"479488","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kaneko, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"479489","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minamimoto, Takafumi"}],"nameIdentifiers":[{"nameIdentifier":"479490","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inoue, Haruhisa"}],"nameIdentifiers":[{"nameIdentifier":"479491","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeuchi, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"479492","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kumata, Katsushi"}],"nameIdentifiers":[{"nameIdentifier":"479493","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"479494","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"479495","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seki, Chie"}],"nameIdentifiers":[{"nameIdentifier":"479496","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ono, Maiko"}],"nameIdentifiers":[{"nameIdentifier":"479497","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tokunaga, Masaki"}],"nameIdentifiers":[{"nameIdentifier":"479498","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsukamoto, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"479499","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanabe, Koji"}],"nameIdentifiers":[{"nameIdentifier":"479500","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shin, Ryong-Moon"}],"nameIdentifiers":[{"nameIdentifier":"479501","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minamihisamatsu, Takeharu"}],"nameIdentifiers":[{"nameIdentifier":"479502","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kito, Seiji"}],"nameIdentifiers":[{"nameIdentifier":"479503","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"J., Richmond Barry"}],"nameIdentifiers":[{"nameIdentifier":"479504","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"479505","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"479506","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"季 斌","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"479507","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"南本 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Neurons in Living Brain and Their Application to Implantation of iPSC-derived Neural Progenitors"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:35:40.681316+00:00"}