@article{oai:repo.qst.go.jp:00047761,
 author = {Urushihata, Takuya and Takuwa, Hiroyuki and Higuchi, Yukako and Sakata, Kazumi and Wakabayashi, Tokumitsu and Nishino, Asuka and Matsuura, Tetsuya and 漆畑 拓弥 and 田桑 弘之 and 西野 明日香},
 issue = {10},
 journal = {Bioscience, biotechnology, and biochemistry},
 month = {Jun},
 note = {The effects of caffeine on salt chemotaxis learning were investigated using the nematode Caenorhabditis elegans. To estimate the degree of salt chemotaxis learning, nematodes were placed in a mixed solution of NaCl and caffeine, and then the chemotaxis index of NaCl was obtained from the nematodes placed on agar medium after pre-exposure to caffeine concentrations of 0.01, 0.1, 0.3, and 1.0%. Locomotor activity and preference behavior for caffeine were also estimated under these caffeine conditions. Nematodes pre-exposed to 0.3% caffeine showed inhibition of salt chemotaxis learning. Additional experiments indicated that nematodes showed a preference response to the middle concentration of caffeine (0.1%), with preference behavior declining in the 0.3% caffeine condition. Stable locomotor activity was observed under 0.01-0.3% caffeine conditions. These results suggest that salt chemotaxis learning with 0.3% caffeine is useful for investigating the effects of caffeine on learning in nematodes.},
 pages = {1990--1994},
 title = {Inhibitory effects of caffeine on gustatory plasticity in the nematode Caenorhabditis elegans.},
 volume = {80},
 year = {2016}
}