@article{oai:repo.qst.go.jp:00047713,
 author = {Fukunaga, Hisanori and Yokoya, Akinari and Taki, Yasuyuki and 横谷 明徳},
 issue = {2},
 journal = {International journal of radiation oncology, biology, physics},
 month = {Oct},
 note = {Individual variation in radiation sensitivity has been investigated for innovative radiation protection and therapy. For instance, some single nucleotide polymorphisms (SNPs) have been reported as potential biomarkers for predicting the development of radiation pneumonitis (RP), one of the adverse effects of radiation therapy . Such SNPs in DNA repair–related, cell signaling–related, and inflammation-related genes have been statistically proven to be associated with RP, suggesting direct or indirect involvement in radiation sensitivity. As of May 31, 2016, we had estimated the frequency of SNPs among the Japanese general population using the Integrative Japanese Genome Variation Database (iJGVD; available at https://ijgvd.megabank.tohoku.ac.jp/), a database based on whole genome sequencing of 1070 Japanese individuals 6 and 7, to investigate the individual variation in radiation sensitivity and potential low-dose radiation-induced health risk in Fukushima after the 2011 nuclear power plant accident. With the assumption of the Hardy-Weinberg equilibrium, a large number of individuals have SNPs associated with the risk of developing RP, indicating that the genetic diversity of radiation sensitivity is greater than expected. Applying genetic variations, the personalized effective dose will be essential for providing next-generation radiation protection and therapy and for estimating the personal radiation-induced health risks for individuals experiencing effects from the Fukushima nuclear crisis. Although public health administrators and medical professionals should continue to make concerted efforts to minimize the radiation-induced risks for citizens, especially children, there appears to have been too little consideration of their genetic background and how it might affect their radiation sensitivity. Also, radiation biologists and oncologists should work to identify the rigorous predictors of radiation sensitivity and prepare the weighting factors.},
 pages = {479--480},
 title = {Now Is the Time to Consider Personalized Effective Dose.},
 volume = {96},
 year = {2016}
}