{"created":"2023-05-15T14:37:01.287468+00:00","id":47711,"links":{},"metadata":{"_buckets":{"deposit":"5056d545-b77e-41d7-be39-45c6a3a655a3"},"_deposit":{"created_by":1,"id":"47711","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47711"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047711","sets":["1"]},"author_link":["478763","478766","478760","478762","478764","478759","478761","478765"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"732","bibliographicPageStart":"724","bibliographicVolumeNumber":"92","bibliographic_titles":[{"bibliographic_title":"International journal of radiation biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: To investigate an enhancement of DNA double-strand break (DSB) induction and cell killing effect by K-shell ionization of phosphorus atoms and Auger electrons on human cell lines.\nMaterials and methods: Induction of DSB, DNA damage responses, cell cycle distributions, and cell killing effects were investigated after exposures of the cells with monochromatic synchrotron radiation soft X-rays of 2153 and 2147 eV, which were the resonance peak and off peak, respectively, of the K-shell photoabsorption of phosphorus.\nResults: Higher biological effects in the cells irradiated with soft X-rays at 2153 eV than at 2147 eV were observed in (i) the efficiency of 53BP1/γ-H2AX co-localized foci formation per dose and residual number of foci, (ii) prolonged phosphorylation levels of DSB repair and/or cell cycle checkpoint related proteins and G2 arrest, (iii) the cell killing effects at the 10% survival level of normal human fibroblasts, HeLa cells, and human glioblastoma M059K cells (1.2–1.5 times higher) and that of human ataxia telangiectasia mutated (ATM)-defective cells and glioblastoma DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-defective cells (1.2 times).\nConclusion: The yield of DSB and partly less-reparable complex DNA damage induction in human cells was enhanced by K-shell photoabsorption of phosphorus and low-energy Auger electrons.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"27185241","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1080/09553002.2016.1179811","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0955-3002","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tomita, Masanori"}],"nameIdentifiers":[{"nameIdentifier":"478759","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Munetoshi"}],"nameIdentifiers":[{"nameIdentifier":"478760","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Usami, Noriko"}],"nameIdentifiers":[{"nameIdentifier":"478761","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokoya, Akinari"}],"nameIdentifiers":[{"nameIdentifier":"478762","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Ritsuko"}],"nameIdentifiers":[{"nameIdentifier":"478763","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Katsumi"}],"nameIdentifiers":[{"nameIdentifier":"478764","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"横谷 明徳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478765","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"横谷 立子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"478766","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Enhancement of DNA double-strand break induction and cell killing by K-shell absorption of phosphorus in human cell lines.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Enhancement of DNA double-strand break induction and cell killing by K-shell absorption of phosphorus in human cell lines."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-04-19"},"publish_date":"2017-04-19","publish_status":"0","recid":"47711","relation_version_is_last":true,"title":["Enhancement of DNA double-strand break induction and cell killing by K-shell absorption of phosphorus in human cell lines."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:36:23.792230+00:00"}