@article{oai:repo.qst.go.jp:00047667,
 author = {Ishikawa, Kenichi and Saegusa, Kumiko and Ootsuka, Yoshimi and Ishikawa, Atsuko and Kawai, Seiko and Yasuda, Kaori and Suga, Tomo and Michikawa, Yuichi and Suzuki, Masao and Iwakawa, Mayumi and Imai, Takashi and 石川 顕一 and 三枝 公美子 and 荘司 好美 and 石川 敦子 and 川井 聖子 and 安田 香央里 and 菅 智 and 道川 祐市 and 鈴木 雅雄 and 岩川 眞由美 and 今井 高志},
 issue = {1},
 journal = {International Journal of Radiation Oncology Biology Physics},
 month = {Mar},
 note = {PURPOSE: To identify gene expression profiles specific to radioresistance of human cells. METHODS AND MATERIALS: Global gene expression profiles of a total of 15 tumor and normal fibroblast cell lines were analyzed using DNA microarrays and statistical clustering methods. Initially, six of the cell lines were categorized into radioresistant (RG) or nonradioresistant (NRG) groups according to the radiation dose required to reduce their survival to 10% (D10). Genes for which expression was specific to each group at 1 or 3 h after irradiation were identified using statistical procedures including analysis of variance and a two-dimensional hierarchical clustering method. The remaining nine cell lines were subjected to the k-nearest neighbor pattern classification. RESULTS: The nine test cell lines were successfully classified by their D10 value using 46 and 44 genes for which transcription levels had significantly changed at 1 and 3 h after irradiation, respectively. Of these genes, 25 showed altered expression at both time points in the NRG or RG, but independently were unable to classify the test cell lines. CONCLUSIONS: Radioresistant cell lines analyzed in this study showed certain radiation-induced changes in gene expression profiles that are different from the profile changes of the more-sensitive cell lines.},
 pages = {234--245},
 title = {Gene expression profile changes correlating with radioresistance in human cell lines},
 volume = {65},
 year = {2006}
}