@article{oai:repo.qst.go.jp:00047664,
 author = {Suga, Tomo and Iwakawa, Mayumi and Tsuji, Hiroshi and Ishikawa, Hitoshi and Oda, Eisei and Noda, Shuhei and Ootsuka, Yoshimi and Ishikawa, Atsuko and Ishikawa, Kenichi and Shimazaki, Jun and Mizoe, Junetsu and Tsujii, Hirohiko and Imai, Takashi and 菅 智 and 岩川 眞由美 and 辻 比呂志 and 石川 仁 and 小田 英世 and 野田 秀平 and 荘司 好美 and 石川 敦子 and 石川 顕一 and 島崎 淳 and 溝江 純悦 and 辻井 博彦 and 今井 高志},
 issue = {3},
 journal = {International Journal of Radiation Oncology Biology Physics},
 month = {Apr},
 note = {Purpose: 
To investigate the genetic risk of late urinary morbidity after carbon ion radiotherapy in prostate cancer patients.
Methods and Materials: 
A total of 197 prostate cancer patients who had undergone carbon ion radiotherapy were evaluated for urinary morbidity. The distribution of patients with dysuria was as follows: Grade 0, 165; Grade 1, 28; and Grade 2, 4 patients. The patients were divided (2:1) consecutively into the training and test sets and then categorized into control (Grade 0) and case (Grade 1 or greater) groups. First, 450 single nucleotide polymorphisms (SNPs) in 118 candidate genes were genotyped in the training set. The associations between the SNP genotypes and urinary morbidity were assessed using Fisher's exact test. Then, various combinations of the markers were tested for their ability to maximize the area under the receiver operating characteristics (AUC-ROC) curve analysis results. Finally, the test set was validated for the selected markers.
Results: 
When the SNP markers in the SART1, ID3, EPDR1, PAH, and XRCC6 genes in the training set were subjected to AUC-ROC curve analysis, the AUC-ROC curve reached a maximum of 0.86. The AUC-ROC curve of these markers in the test set was 0.77. The SNPs in these five genes were defined as "risk genotypes." Approximately 90% of patients in the case group (Grade 1 or greater) had three or more risk genotypes.
Conclusions: 
Our results have shown that patients with late urinary morbidity after carbon ion radiotherapy can be stratified according to the total number of risk genotypes they harbor.},
 pages = {808--813},
 title = {Influence of Multiple Genetic Polymorphisms on Genitourinary Morbidity After Carbon Ion Radiotherapy for Prostate Cancer},
 volume = {72},
 year = {2008}
}