{"created":"2023-05-15T14:36:57.867460+00:00","id":47634,"links":{},"metadata":{"_buckets":{"deposit":"b37a2da0-fb90-44b1-991b-c38983fd2d11"},"_deposit":{"created_by":1,"id":"47634","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47634"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047634","sets":["1"]},"author_link":["477685","477695","477686","477694","477690","477689","477693","477696","477691","477692","477687","477688"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"219","bibliographicPageStart":"210","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In vivo neutron-induced radioadaptive response (RAR) was studied using zebrafish (Danio rerio) embryos. The Neutron exposure Accelerator System for Biological Effect Experiments (NASBEE) facility at the National Institute of Radiological Sciences (NIRS), Japan, was employed to provide 2-MeV neutrons. Neutron doses of 0.6, 1, 25, 50 and 100 mGy were chosen as priming doses. An X-ray dose of 2 Gy was chosen as the challenging dose. Zebrafish\nembryos were dechorionated at 4 h post fertilization (hpf ), irradiated with a chosen neutron dose at 5 hpf and the X-ray dose at 10 hpf. The responses of embryos were assessed at 25 hpf through the number of apoptotic signals.\nNone of the neutron doses studied could induce RAR. Non-induction of RAR in embryos having received 0.6- and 1-mGy neutron doses was attributed to neutron-induced hormesis, which maintained the number of damaged cells\nat below the threshold for RAR induction. On the other hand, non-induction of RAR in embryos having received 25-, 50- and 100-mGy neutron doses was explained by gamma-ray hormesis, which mitigated neutron-induced\ndamages through triggering high-fidelity DNA repair and removal of aberrant cells through apoptosis. Separate experimental results were obtained to verify that high-energy photons could disable RAR. Specifically, 5- or 10-mGy X-rays disabled the RAR induced by a priming dose of 0.88 mGy of alpha particles delivered to 5-hpf zebrafish embryos against a challenging dose of 2 Gy of X-rays delivered to the embryos at 10 hpf.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"oxford university press"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"26850927","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1093/jrr/rrv089","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://jrr.oxfordjournals.org/content/57/3/210.full.pdf+html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://jrr.oxfordjournals.org/content/57/3/210.full.pdf+html","subitem_relation_type_select":"URI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Y., P. Ng Candy"}],"nameIdentifiers":[{"nameIdentifier":"477685","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Y., Kong Eva"}],"nameIdentifiers":[{"nameIdentifier":"477686","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Alisa"}],"nameIdentifiers":[{"nameIdentifier":"477687","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suya, Noriyoshi"}],"nameIdentifiers":[{"nameIdentifier":"477688","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uchihori, Yukio"}],"nameIdentifiers":[{"nameIdentifier":"477689","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Han, Cheng Shuk"}],"nameIdentifiers":[{"nameIdentifier":"477690","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Konishi, Teruaki"}],"nameIdentifiers":[{"nameIdentifier":"477691","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ngok, Yu Kwan"}],"nameIdentifiers":[{"nameIdentifier":"477692","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林 亜利紗","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"477693","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"酢屋 徳啓","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"477694","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"内堀 幸夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"477695","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小西 輝昭","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"477696","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Non-induction of radioadaptive response in zebrafish embryos by neutrons","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Non-induction of radioadaptive response in zebrafish embryos by neutrons"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-02-08"},"publish_date":"2017-02-08","publish_status":"0","recid":"47634","relation_version_is_last":true,"title":["Non-induction of radioadaptive response in zebrafish embryos by neutrons"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:37:21.019795+00:00"}