@article{oai:repo.qst.go.jp:00047567,
 author = {Molinelli, Silvia and Magro, Giuseppe and Mairani, Andrea and Matsufuji, Naruhiro and Kanematsu, Nobuyuki and Inaniwa, Taku and Mirandola, Alfredo and Russo, Stefania and Mastella, Edoardo and Hasegawa, Azusa and Tsuji, Hiroshi and Yamada, Shigeru and Vischioni, Barbara and Vitolo, Viviana and Ferrari, Alfredo and Ciocca, Mario and Kamada, Tadashi and Tsujii, Hirohiko and Orecchia, Roberto and Fossati, Piero and Ｍｏｌｉｎｅｌｌｉ Ｓｉｌｖｉａ and Ｍａｉｒａｎｉ Ａｎｄｒｅａ and 松藤 成弘 and 兼松 伸幸 and 稲庭 拓 and 長谷川 安都佐 and 辻 比呂志 and 山田 滋 and Ｖｉｓｃｈｉｏｎｉ Ｂａｒｂａｒａ and 鎌田 正 and 辻井 博彦 and Ｆｏｓｓａｔｉ Ｐｉｅｒｏ},
 issue = {2},
 journal = {Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
 month = {Aug},
 note = {Background and purpose
In carbon ion radiotherapy (CIRT), the use of different relative biological effectiveness (RBE) models in the RBE-weighted dose (DRBE) calculation can lead to deviations in the physical dose (Dphy) delivered to the patient. Our aim is to reduce target Dphy deviations by converting prescription dose values.
\nMaterial and methods
Planning data of patients treated at the National Institute of Radiological Sciences (NIRS) were collected, with prescribed doses per fraction ranging from 3.6 Gy (RBE) to 4.6 Gy (RBE), according to the Japanese semi-empirical model. The Dphy was Monte Carlo (MC) re-calculated simulating the NIRS beamline. The local effect model (LEM)_I was then applied to estimate DRBE. Target median DRBE ratios between MC + LEM_I and NIRS plans determined correction factors for the conversion of prescription doses. Plans were re-optimized in a LEM_I-based commercial system, prescribing the NIRS uncorrected and corrected DRBE.
\nResults
The MC + LEM_I target median DRBE was respectively 15% and 5% higher than the NIRS reference, for the lowest and highest dose levels. Uncorrected DRBE prescription resulted in significantly lower target Dphy in re-optimized plans, with respect to NIRS plans.
\nConclusions
Prescription dose conversion factors could minimize target physical dose variations due to the use of different radiobiological models in the calculation of CIRT RBE-weighted dose.},
 pages = {307--312},
 title = {Dose prescription in carbon ion radiotherapy: How to compare two different RBE-weighted dose calculation systems},
 volume = {120},
 year = {2016}
}