@article{oai:repo.qst.go.jp:00047548, author = {Yamasaki, Kosuke and Sakuma, Yasunobu and Sasaki, Junya and Ken-ichiro, Matsumoto and Anzai, Kazunori and Matsuoka, Keisuke and Honda, Chikako and Tsukada, Masamichi and Endo, Kazutoyo and Enomoto, Shuichi and Matsumoto, Kenichiro and Anzai, Kazunori}, issue = {8}, journal = {Analytical and Bioanalytical Chemistry}, month = {Nov}, note = {The excretion of essential trace elements, namely, Se, Sr, As, Mn, Co, V, Fe, and Zn into the bile of Se-deficient (SeD) Wistar male rats was studied using the multitracer (MT) technique, and instrumental neutron activation analysis (INAA). Normal and Se-control (SeC) rat groups were used as reference groups to compare the effects of Se levels on the behaviors of the essential trace elements. The excretion (% dose) of Se, Sr, As, Mn, Co, and V increased with Se levels in the liver. The biliary excretion of Mn and As dramatically enhanced for SeC rats compared with SeD rats, while that of V accelerated a little for SeC rats. The radioactivity levels of Fe-59 and Zn-65 in the MT tracer solution were insufficient to measure their excretion into bile. The role of glutathione and bilirubin for biliary excretion of the metals was discussed in relation to Se levels in rat liver.}, pages = {2531--2538}, title = {Biliary excretion of essential trace elements in rats under oxidative stress caused by selenium deficiency}, volume = {401}, year = {2011} }