{"created":"2023-05-15T14:36:51.881051+00:00","id":47498,"links":{},"metadata":{"_buckets":{"deposit":"0791e9dd-bb22-47ef-958e-9cfe04b7ceff"},"_deposit":{"created_by":1,"id":"47498","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47498"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047498","sets":["1"]},"author_link":["475925","475926","475923","475924","475927"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"1361","bibliographicPageStart":"1351","bibliographicVolumeNumber":"106","bibliographic_titles":[{"bibliographic_title":"Cancer Science"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Neuroblastoma (NB) is the most common extracranial solid tumor that originates from multipotent neural crest cells. NB cell populations which express embryonic stem cell-associated genes have been identified and shown to retain a multipotent phenotype. However, whether somatic reprogramming of NB cells can produce similar stem-cell like populations is unknown. Here, we sought to reprogram NB cell lines using an integration-free Sendai virus vector system. Of four NB cell lines examined, only SH-IN cells formed induced pluripotent stem cell-like colonies (SH-IN 4F colonies) at approximately 6 weeks following transduction. These SH-IN 4F colonies were alkaline phosphatase-positive. Array comparative genomic hybridization analysis indicated identical genomic aberrations in the SH-IN 4F cells as in the parental cells. SH-IN 4F cells had the ability to differentiate into the three embryonic germ layers in vitro, but rather formed NBs in vivo. Furthermore, SH-IN 4F cells exhibited resistance to cisplatin treatment and differentiated into endothelial-like cells expressing CD31 in the presence of vascular endothelial growth factor. These results suggest that SH-IN 4F cells are partially reprogrammed NB cells, and could be a suitable model for investigating the plasticity of aggressive tumors. This article is protected by copyright. All rights reserved.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"WILEY"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/cas.12746","subitem_relation_type_select":"DOI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Islam, Rafiqul"}],"nameIdentifiers":[{"nameIdentifier":"475923","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suenaga, Y"}],"nameIdentifiers":[{"nameIdentifier":"475924","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takatori, A"}],"nameIdentifiers":[{"nameIdentifier":"475925","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"al., et"}],"nameIdentifiers":[{"nameIdentifier":"475926","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"イスラム ラフィクル","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475927","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Sendai virus-mediated expression of reprogramming factors promotes plasticity of human neuroblastoma cells.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Sendai virus-mediated expression of reprogramming factors promotes plasticity of human neuroblastoma cells."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-24"},"publish_date":"2016-08-24","publish_status":"0","recid":"47498","relation_version_is_last":true,"title":["Sendai virus-mediated expression of reprogramming factors promotes plasticity of human neuroblastoma cells."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:39:06.041460+00:00"}