@article{oai:repo.qst.go.jp:00047468, author = {Suganami, Akiko and Iwadate, Yasuo and Shibata, Sayaka and Yamashita, Masamichi and Tanaka, Tsutomu and Shinozaki, Natsuki and Aoki, Ichio and Saeki, Naokatsu and Shirasawa, Hiroshi and Okamoto, Yoshiharu and Tamura, Yutaka and 菅波 晃子 and 岩立 康男 and 柴田 さやか and 青木 伊知男 and 田村 裕}, issue = {2}, journal = {International journal of pharmaceutics}, month = {Oct}, note = {Some tumor-specific near-infrared (NIR) fluorescent dyes such as indocyanine green (ICG), IDRye800CW, and 5-aminolevulinic acid have been used clinically for detecting tumor margins or micro-cancer lesions. In this study, we evaluated the physicochemical properties of liposomally formulated phospholipid-conjugated ICG, denoted by LP-iDOPE, as a clinically translatable NIR imaging nanoparticle for brain tumors. We also confirmed its brain-tumor-specific biodistribution and its characteristics as the intra-operative NIR imaging nanoparticles for brain tumor surgery. These properties of LP-iDOPE may enable neurosurgeons to achieve more accurate identification and more complete resection of brain tumor.}, pages = {401--406}, title = {Liposomally formulated phospholipid-conjugated indocyanine green for intra-operative brain tumor detection and resection.}, volume = {496}, year = {2015} }