{"created":"2023-05-15T14:36:50.297174+00:00","id":47462,"links":{},"metadata":{"_buckets":{"deposit":"fb10fd77-8795-46ee-bcbf-22f023b602cb"},"_deposit":{"created_by":1,"id":"47462","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47462"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047462","sets":["1"]},"author_link":["475471","475479","475470","475468","475480","475469","475478","475466","475475","475476","475477","475473","475474","475465","475464","475472","475467","475481"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"409","bibliographicPageStart":"398","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"World Journal of Oncology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The aim of the study was to clarify the effect of p53\nstatus of tumor cells on radiosensitivity of solid tumors following accelerated\ncarbon-ion beam irradiation compared with γ-rays or reactor\nneutron beams, referring to the response of intratumor quiescent\n(Q) cells.\nMethods: Human head and neck squamous cell carcinoma cells transfected\nwith mutant TP53 (SAS/mp53) or with neo vector (SAS/neo)\nwere injected subcutaneously into hind legs of nude mice. Tumorbearing\nmice received 5-bromo-2’-deoxyuridine (BrdU) continuously\nto label all intratumor proliferating (P) cells. They received γ-rays or\naccelerated carbon-ion beams at a high or reduced dose-rate. Other\ntumor-bearing mice received reactor thermal or epithermal neutrons\nat a reduced dose-rate. Immediately or 9 hours after the high doserate\nirradiation (HDRI), or immediately after the reduced dose-rate\nirradiation (RDRI), the tumor cells were isolated and incubated with\na cytokinesis blocker, and the micronucleus (MN) frequency in cells\nwithout BrdU labeling (Q cells) was determined using immunofluorescence\nstaining for BrdU.\nResults: The difference in radiosensitivity between the total (P + Q)\nand Q cells after γ-ray irradiation was markedly reduced with reactor\nneutron beams or carbon-ion beams, especially with a higher linear\nenergy transfer (LET) value. Following γ-ray irradiation, SAS/neo\ntumor cells, especially intratumor Q cells, showed a marked reduction\nin sensitivity due to the recovery from radiation-induced damage,\ncompared with the total or Q cells within SAS/mp53 tumors that\nshowed little repair capacity. In both total and Q cells within both\nSAS/neo and SAS/mp53 tumors, carbon-ion beam irradiation, especially\nwith a higher LET, showed little recovery capacity through\nleaving an interval between HDRI and the assay or decreasing the\ndose-rate. The recovery from radiation-induced damage after γ-ray\nirradiation was a p53-dependent event, but little recovery was found\nafter carbon-ion beam irradiation. With RDRI, the radiosensitivity\nto reactor thermal and epithermal neutron beams was slightly higher\nthan that to carbon-ion beams.\nConclusion: For tumor control, including intratumor Q-cell control,\naccelerated carbon-ion beams, especially with a higher LET, and reactor\nthermal and epithermal neutron beams were very useful for suppressing\nthe recovery from radiation-induced damage irrespective of\np53 status of tumor cells.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"World J Oncol and Elmer Press Inc"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.14740/wjon941w","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1920-454X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"増永, 慎一郎"}],"nameIdentifiers":[{"nameIdentifier":"475464","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鵜澤, 玲子"}],"nameIdentifiers":[{"nameIdentifier":"475465","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平山, 亮一"}],"nameIdentifiers":[{"nameIdentifier":"475466","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本, 孔貴"}],"nameIdentifiers":[{"nameIdentifier":"475467","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakurai, Yoshinori"}],"nameIdentifiers":[{"nameIdentifier":"475468","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 浩基"}],"nameIdentifiers":[{"nameIdentifier":"475469","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tano, Keizo"}],"nameIdentifiers":[{"nameIdentifier":"475470","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sanada, Yu"}],"nameIdentifiers":[{"nameIdentifier":"475471","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Minoru"}],"nameIdentifiers":[{"nameIdentifier":"475472","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丸橋, 晃"}],"nameIdentifiers":[{"nameIdentifier":"475473","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小野, 公二"}],"nameIdentifiers":[{"nameIdentifier":"475474","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"増永 慎一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475475","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鵜澤 玲子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475476","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平山 亮一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475477","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 孔貴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475478","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 浩基","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475479","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"丸橋 晃","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475480","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小野 公二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"475481","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Effect of p53 Status of Tumor Cells on Radiosensitivity of Irradiated Tumors With Carbon-Ion Beams Compared With γ-Rays or Reactor Neutron Beams","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Effect of p53 Status of Tumor Cells on Radiosensitivity of Irradiated Tumors With Carbon-Ion Beams Compared With γ-Rays or Reactor Neutron Beams"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-10"},"publish_date":"2016-08-10","publish_status":"0","recid":"47462","relation_version_is_last":true,"title":["The Effect of p53 Status of Tumor Cells on Radiosensitivity of Irradiated Tumors With Carbon-Ion Beams Compared With γ-Rays or Reactor Neutron Beams"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:39:33.546243+00:00"}