{"created":"2023-05-15T14:36:48.670859+00:00","id":47425,"links":{},"metadata":{"_buckets":{"deposit":"3b96c11b-de95-47e7-9f6c-4c27f01fd393"},"_deposit":{"created_by":1,"id":"47425","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47425"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047425","sets":["1"]},"author_link":["474967","474971","474955","474969","474954","474956","474972","474953","474957","474963","474973","474952","474968","474974","474965","474966","474970","474959","474958","474964","474960","474962","474961"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"17327","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"Scientific Reports (Online Only URL:http://www.nature.com/srep/index.html)"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hepatic fibrosis is the wound healing response to chronic hepatic injury caused by various factors.\nIn this study, we aimed to evaluate the utility of translocator protein (18 kDa) (TSPO) as a molecular\nimaging biomarker for monitoring the progression of hepatic fibrosis to cirrhosis. Model rats were\ninduced by carbon tetrachloride (CCl4), and liver fibrosis was assessed. Positron emission tomography\n(PET) with N-benzyl-N-methyl-2-[7,8-dihydro-7-(2-[18F]fluoroethyl)-8-oxo-2-phenyl-9H-purin-9-yl]\n-acetamide ([18F]FEDAC), a radioprobe specific for TSPO, was used for noninvasive visualisation\nin vivo. PET scanning, immunohistochemical staining, ex vivo autoradiography, and quantitative\nreverse-transcription polymerase chain reaction were performed to elucidate the relationships\namong radioactivity uptake, TSPO levels, and cellular sources enriching TSPO expression in damaged\nlivers. PET showed that uptake of radioactivity in livers increased significantly after 2, 4, 6, and 8\nweeks of CCl4 treatment. Immunohistochemistry demonstrated that TSPO was mainly expressed in\nmacrophages and hepatic stellate cells (HSCs). TSPO-expressing macrophages and HSCs increased\nwith the progression of liver fibrosis. Interestingly, the distribution of radioactivity from [18F]FEDAC\nwas well correlated with TSPO expression, and TSPO mRNA levels increased with the severity of liver\ndamage. TSPO was a useful molecular imaging biomarker and could be used to track the progression\nof hepatic fibrosis to cirrhosis with PET.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"26612465","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"DOI: 10.1038/srep17327","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"www.nature.com/scientificreports"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"www.nature.com/scientificreports","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hatori, Akiko"}],"nameIdentifiers":[{"nameIdentifier":"474952","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yui, Joji"}],"nameIdentifiers":[{"nameIdentifier":"474953","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Xie, Lin"}],"nameIdentifiers":[{"nameIdentifier":"474954","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kumata, Katsushi"}],"nameIdentifiers":[{"nameIdentifier":"474955","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamasaki, Tomoteru"}],"nameIdentifiers":[{"nameIdentifier":"474956","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujinaga, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"474957","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakizaka, Hidekatsu"}],"nameIdentifiers":[{"nameIdentifier":"474958","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, Masanao"}],"nameIdentifiers":[{"nameIdentifier":"474959","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nengaki, Nobuki"}],"nameIdentifiers":[{"nameIdentifier":"474960","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawamura, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"474961","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wang, Feng"}],"nameIdentifiers":[{"nameIdentifier":"474962","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"474963","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474964","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474965","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝 琳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474966","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474967","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474968","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474969","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474970","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川 政直","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474971","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣 信樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474972","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474973","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474974","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Utility of Translocator Protein (18 kDa) as a Molecular Imaging Biomarker to Monitor the Progression of Liver Fibrosis        ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Utility of Translocator Protein (18 kDa) as a Molecular Imaging Biomarker to Monitor the Progression of Liver Fibrosis        "}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-05-19"},"publish_date":"2016-05-19","publish_status":"0","recid":"47425","relation_version_is_last":true,"title":["Utility of Translocator Protein (18 kDa) as a Molecular Imaging Biomarker to Monitor the Progression of Liver Fibrosis        "],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:40:00.457078+00:00"}