@article{oai:repo.qst.go.jp:00047423,
 author = {Miura, Yutaka and Tsuji, Atsushi and Sugyo, Aya and Sudo, Hitomi and Aoki, Ichio and Inubushi, Masayuki and Yashiro, Masakazu and Hirakawa, Kosei and Cabral, Horacio and Nishiyama, Nobuhiro and Saga, Tsuneo and Kataoka, Kazunori and 辻 厚至 and 須尭 綾 and 須藤 仁美 and 青木 伊知男 and 犬伏 正幸 and 佐賀 恒夫},
 issue = {11},
 journal = {ACS Biomaterials Science & Engineering},
 month = {Sep},
 note = {Scirrhous gastric cancer (SGC) is a recalcitrant tumor, which is among the most lethal cancers. A critical issue for the improvement of SGC prognosis is the lack of an effective imaging method for accurate detection and diagnosis.
Because combined nuclear medicine imaging with magnetic resonance imaging (MRI) has the ability to detect cancer with high sensitivity, and quantitation and spatial resolution, it has potential to overcome the issues with SGC detection.
Herein, we designed and synthesized a new block copolymer poly(ethylene glycol)-b-poly(γ-benzyl L-glutamate) linked with a chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA-PEG-b-PBLG) to provide a platform for multimodal tomographic imaging. We then successfully prepared DOTA-functionalized polymeric micelles (DOTA/m) measuring 30 nm in diameter, which is an appropriate size to penetrate deeply into tumors with thick fibrosis, including SGC. 111In-labeled DOTA/m highly accumulated in Colon-26 tumors (mouse colon cancer with hyperpermeability), but also in OCUM-2 M LN tumors (SGC with hypopermeability), clearly depicting both tumors by single photon emission computed tomography (SPECT).
Gd-labeled DOTA/m clearly visualized OCUM-2 M LN tumors by MRI with high spatial resolution. Moreover, 111In/Gdlabeled micelles, as well as the mixture of 111In- and Gd-labeled DOTA/m demonstrated the capability of this system for selective multimodal SPECT/MR imaging of SCG. Our findings support 111In/Gd-DOTA-labeled micelles as a clinical translationable modality for multimodal tomographic imaging capable of detecting SGC},
 pages = {1067--1076},
 title = {Polymeric Micelle Platform for Multimodal Tomographic Imaging to Detect Scirrhous Gastric Cancer},
 volume = {1},
 year = {2015}
}