{"created":"2023-05-15T14:36:46.478934+00:00","id":47379,"links":{},"metadata":{"_buckets":{"deposit":"09254046-ed0a-4cee-9567-dbfb16b3a068"},"_deposit":{"created_by":1,"id":"47379","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47379"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047379","sets":["1"]},"author_link":["474271","474279","474269","474276","474251","474274","474260","474270","474256","474275","474263","474257","474262","474273","474278","474261","474264","474282","474277","474267","474266","474255","474252","474272","474281","474253","474254","474268","474265","474259","474280","474258"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"910","bibliographicPageStart":"905","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"Nuclear Medicine and Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction: [11C]PBB3 is a clinically used positron emission tomography\n(PET) probe for in vivo imaging of tau pathology in the brain. Our previous\nstudy showed that [11C]PBB3 was rapidly decomposed to a polar\nradiometabolite in the plasma of mice. For the pharmacokinetic evaluation\nof [11C]PBB3 it is important to elucidate the characteristics of\nradiometabolites. In this study, we identified the chemical structure of a\nmajor radiometabolite of [11C]PBB3 and proposed the metabolic pathway of\n[11C]PBB3.\nMethods: Carrier-added [11C]PBB3 was injected into a mouse for in vivo\nmetabolite analysis. The chemical structure of a major radiometabolite was\nidentified using LC–MS. Mouse and human liver microsomes and liver S9\nsamples were incubated with [11C]PBB3 in vitro. In silico prediction\nsoftware was used to assist in the determination of the metabolite and\nmetabolic pathway of [11C]PBB3.\nResults: In vivo analysis showed that the molecular weight of a major\nradiometabolite of [11C]PBB3, which was called as [11C]M2, was m/z 390\n[M+H+]. In vitro analysis assisted by in silico prediction showed that\n[11C]M2, which was not generated by cytochrome P450 enzymes (CYPs),\nwas generated by sulfated conjugation mediated by a sulfotransferase.\nConclusion: The major radiometabolite, [11C]M2, was identified as a\nsulfated conjugate of [11C]PBB3. [11C]PBB3 was metabolized mainly by a sulfotransferase and subsidiarily by CYPs.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"26420569","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"doi:10.1016/j.nucmedbio.2015.08.006","subitem_relation_type_select":"DOI"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hashimoto, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"474251","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawamura, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"474252","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takei, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"474253","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Igarashi, Nobuyuki"}],"nameIdentifiers":[{"nameIdentifier":"474254","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujishiro, Tomoya"}],"nameIdentifiers":[{"nameIdentifier":"474255","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shiomi, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"474256","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ryuji, Watanabe"}],"nameIdentifiers":[{"nameIdentifier":"474257","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Muto, Masatoshi"}],"nameIdentifiers":[{"nameIdentifier":"474258","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furutsuka, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"474259","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Takehito"}],"nameIdentifiers":[{"nameIdentifier":"474260","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamasaki, Tomoteru"}],"nameIdentifiers":[{"nameIdentifier":"474261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yui, Joji"}],"nameIdentifiers":[{"nameIdentifier":"474262","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nemoto, Kazuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"474263","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yasuyuki"}],"nameIdentifiers":[{"nameIdentifier":"474264","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"474265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"474266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本 裕輝","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武井 誠","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474269","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"五十嵐 延行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474270","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤代 智也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474271","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"潮見 聡","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474272","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡辺 竜二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474273","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武藤 正敏","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474274","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古塚 賢士","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474275","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 岳人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474276","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474277","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474278","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根本 和義","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474279","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 泰之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474280","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474281","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"474282","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Identification of a major radiometabolite of [11C]PBB3","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Identification of a major radiometabolite of [11C]PBB3"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-01-18"},"publish_date":"2016-01-18","publish_status":"0","recid":"47379","relation_version_is_last":true,"title":["Identification of a major radiometabolite of [11C]PBB3"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:40:33.205303+00:00"}