@article{oai:repo.qst.go.jp:00047357, author = {Ng, C.Y.P. and Kong, E.Y. and Kobayashi, Alisa and Suya, Noriyoshi and Uchihori, Yukio and Cheng, S.H. and Konishi, Teruaki and Yu, K.N. and 小林 亜利紗 and 酢屋 徳啓 and 内堀 幸夫 and 小西 輝昭}, journal = {Radiation Physics and Chemistry}, month = {Aug}, note = {The present paper reported the first-ever observation of neutron induced bystander effect (NIBE) using zebrafish (Danio rerio) embryos as the in vivo model. The neutron exposure in the present work was provided by the Neutron exposure Accelerator System for Biological Effect Experiments (NASBEE) facility at the National Institute of Radiological Sciences (NIRS), Chiba, Japan. Two different strategies were employed to induce NIBE, namely, through directly partnering and through medium transfer. Both results agreed with a neutron-dose window (20–50 mGy) which could induce NIBE. The lower dose limit corresponded to the threshold amount of neutron-induced damages to trigger significant bystander signals, while the upper limit corresponded to the onset of gamma-ray hormesis which could mitigate the neutron-induced damages and thereby suppress the bystander signals. Failures to observe NIBE in previous studies were due to using neutron doses outside the dose-window. Strategies to enhance the chance of observing NIBE included (1) use of a mono-energetic high-energy (e.g., between 100 keV and 2 MeV) neutron source, and (2) use of a neutron source with a small gamma-ray contamination. It appeared that the NASBEE facility used in the present study fulfilled both conditions, and was thus ideal for triggering NIBE.}, pages = {153--159}, title = {Neutron induced bystander effect among zebrafish embryos}, volume = {117}, year = {2015} }