{"created":"2023-05-15T14:36:44.970985+00:00","id":47345,"links":{},"metadata":{"_buckets":{"deposit":"d15f9a47-bee0-4142-a655-07a5b62a57cf"},"_deposit":{"created_by":1,"id":"47345","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47345"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047345","sets":["1"]},"author_link":["473827","473816","473817","473822","473823","473830","473820","473815","473832","473826","473831","473834","473825","473828","473818","473833","473821","473819","473824","473814","473829","473835"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-09","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"67","bibliographicPageStart":"58","bibliographicVolumeNumber":"779","bibliographic_titles":[{"bibliographic_title":"Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Children are considered more sensitive to radiation-induced cancer than adults, yet any differences ingenomic alterations associated with age-at-exposure and their underlying mechanisms remain unclear.We assessed genome-wide DNA copy number and mutation of key tumor suppressor genes in T-celllymphomas arising after weekly irradiation of female B6C3F1 mice with 1.2 Gy X-rays for 4 consecutiveweeks starting during infancy (1 week old), adolescence (4 weeks old) or as young adults (8 weeks old).Although T-cell lymphoma incidence was similar, loss of heterozygosity at Cdkn2a on chromosome 4 andat Ikaros on chromosome 11 was more frequent in the two older groups, while loss at the Pten locus onchromosome 19 was more frequent in the infant-irradiated group. Cdkn2a and Ikaros mutation/loss wasa common feature of the young adult-irradiation group, with Ikaros frequently (50%) incurring multipleindependent hits (including deletions and mutations) or suffering a single hit predicted to result in adominant negative protein (such as those lacking exon 4, an isoform we have designated Ik12, whichlacks two DNA binding zinc-finger domains). Conversely, Pten mutations were more frequent after earlyirradiation (60%) than after young adult-irradiation (30%). Homozygous Pten mutations occurred withoutDNA copy number change after irradiation starting in infancy, suggesting duplication of the mutatedallele by chromosome mis-segregation or mitotic recombination. Our findings demonstrate that whiledeletions on chromosomes 4 and 11 affecting Cdkn2a and Ikaros are a prominent feature of young adultirradiation-induced T-cell lymphoma, tumors arising after irradiation from infancy suffer a second hit inPten by mis-segregation or recombination. This is the first report showing an influence of age-at-exposureon genomic alterations of tumor suppressor genes and their relative involvement in radiation-inducedT-cell lymphoma. These data are important for considering the risks associated with childhood exposureto radiation.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Ltd."}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.mrfmmm.2015.06.004","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0027-5107","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"砂押, 正章"}],"nameIdentifiers":[{"nameIdentifier":"473814","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"甘崎, 佳子"}],"nameIdentifiers":[{"nameIdentifier":"473815","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂入, しのぶ"}],"nameIdentifiers":[{"nameIdentifier":"473816","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｂｌｙｔｈ, Ｂｅｎｊａｍｉｎ"}],"nameIdentifiers":[{"nameIdentifier":"473817","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森岡, 孝満"}],"nameIdentifiers":[{"nameIdentifier":"473818","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上西, 睦美"}],"nameIdentifiers":[{"nameIdentifier":"473819","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"尚, 奕"}],"nameIdentifiers":[{"nameIdentifier":"473820","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村, まゆみ"}],"nameIdentifiers":[{"nameIdentifier":"473821","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 義也"}],"nameIdentifiers":[{"nameIdentifier":"473822","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"立花, 章"}],"nameIdentifiers":[{"nameIdentifier":"473823","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼, 志津子"}],"nameIdentifiers":[{"nameIdentifier":"473824","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"砂押 正章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473825","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"甘崎 佳子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473826","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂入 しのぶ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473827","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｂｌｙｔｈ Ｂｅｎｊａｍｉｎ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473828","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森岡 孝満","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473829","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上西 睦美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473830","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"尚 奕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473831","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473832","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473833","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"立花 章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473835","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The effect of age at exposure on the inactivating mechanisms and relative contributions of key tumor suppressor genes in radiation-induced mouse T-cell lymphomas","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The effect of age at exposure on the inactivating mechanisms and relative contributions of key tumor suppressor genes in radiation-induced mouse T-cell lymphomas"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-01-18"},"publish_date":"2016-01-18","publish_status":"0","recid":"47345","relation_version_is_last":true,"title":["The effect of age at exposure on the inactivating mechanisms and relative contributions of key tumor suppressor genes in radiation-induced mouse T-cell lymphomas"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:40:55.509423+00:00"}