@article{oai:repo.qst.go.jp:00047339,
 author = {Matsumoto, Ryohei and Ichise, Masanori and Ito, Hiroshi and Ando, Tomomichi and Takahashi, Hidehiko and Ikoma, Yoko and Kosaka, Jun and Arakawa, Ryosuke and Fujimura, Yota and Ota, Miho and Takano, Akihiro and Fukui, Kenji and Nakayama, Kazuhiko and Suhara, Tetsuya and et.al and 松本 良平 and 市瀬 正則 and 伊藤 浩 and 安藤 智道 and 高橋 英彦 and 生駒 洋子 and 小坂 淳 and 荒川 亮介 and 藤村 洋太 and 太田 深秀 and 高野 晶寛 and 須原 哲也},
 issue = {1},
 journal = {NeuroImage},
 month = {Jan},
 note = {The serotonin transporter (5-HTT) and other markers of the serotonergic system have been of interest in the pathophysiology of obsessive-compulsive disorder (OCD). Previous studies using single photon emission computed tomography (SPECT) with [(123)I]beta-CIT or positron emission tomography (PET) with [(11)C]McN5652 have not shown consistent findings about 5-HTT in OCD patients. The aim of the present study was to investigate 5-HTT binding using [(11)C]DASB, which has higher selectivity or specific binding-to-nonspecific binding ratios for 5-HTT compared to the aforementioned radioligands. Four drug-naïve and 6 drug free patients with OCD who were free of comorbid depression and 18 gender and age-matched healthy subjects underwent PET scans with [(11)C]DASB. The severity of OCD was assessed by Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) (mean+/-SD: 22+/-7.6, range: 7-32). The binding potential (BP(ND)) of [(11)C]DASB was calculated using a two-parameter multilinear reference tissue model (MRTM2). The parametric images of BP(ND) were analyzed using a statistical parametric mapping system. Significant reductions of BP(ND) were observed in the right posterior and left anterior insular cortices in patients with OCD compared to controls. Region-of-interest analysis has also confirmed significant reduction of BP(ND) in the insular cortex. Although significantly reduced BP(ND) in the orbitofrontal cortex was also observed in patients with OCD compared to controls, this finding should be considered with caution because of the very low 5-HTT binding in the region. On the other hand, no significant correlation was observed between the Y-BOCS score and BP(ND). The change in [(11)C]DASB binding in the insular cortex suggests that dysfunction of the serotonergic system in the limbic area might be involved in the pathophysiology of OCD.},
 pages = {121--126},
 title = {Reduced serotonin transporter binding in the insular cortex in patients with obsessive compulsive disorder: a [11C]DASB PET study},
 volume = {49},
 year = {2010}
}