@article{oai:repo.qst.go.jp:00047336,
 author = {Ikoma, Yoko and Yasuno, Fumihiko and Ito, Hiroshi and Suhara, Tetsuya and Ota, Miho and Toyama, Hinako and Fujimura, Yota and Takano, Akihiro and Maeda, Jun and Zhang, Ming-Rong and Nakao, Ryuji and Suzuki, Kazutoshi and 生駒 洋子 and 伊藤 浩 and 須原 哲也 and 太田 深秀 and 藤村 洋太 and 高野 晶寛 and 前田 純 and 張 明栄 and 中尾 隆士 and 鈴木 和年},
 issue = {1},
 journal = {Journal of Cerebral Blood Flow and Metabolism},
 month = {Jan},
 note = {[11C]DAA1106 is a potent and selective ligand for the peripheral benzodiazepine receptor (PBR) with high affinity. It has been reported that the density of PBR is related to brain damage, so a reliable tracer method for the evaluation of PBR would be of use. We evaluated a quantification method of [11C]DAA1106 binding in simulated data and human brain data. In the simulation study, the reliability of parameters estimated from the nonlinear least-squares (NLS) method, graphical analysis (GA), and multilinear analysis (MA) was evaluated. In GA, variation of the estimated distribution volume (DV) was small. However, DV was underestimated as noise increased. In MA, bias was smaller, and variation of the estimated DV was larger than in GA. In NLS, although variation was larger than in GA, it was small enough in regions of interest analysis, and not only DV but also binding potential (BP), determined from the k3/k4 without any constraint, could be estimated. The variation of BP estimated with NLS became larger as k3 or k4 became smaller. In human studies with normal volunteers, regions of interest were drawn on several brain regions, BP was calculated by NLS, and DV was also estimated by NLS, GA, and MA. As a result, DVs estimated with each method were well correlated. However, there was no correlation between BP with NLS and DV with NLS, GA, and MA, because of the variation of K1/k2 between individuals. In conclusion, BP is estimated most reliably by NLS with the two-tissue compartment model.},
 pages = {173--184},
 title = {Quantitative analysis for estimating binding potential of the peripheral benzodiazepine receptor with [11C]DAA1106},
 volume = {27},
 year = {2007}
}