{"created":"2023-05-15T14:36:44.356726+00:00","id":47331,"links":{},"metadata":{"_buckets":{"deposit":"e23368a9-aa97-4a56-bc34-2fb0604dea60"},"_deposit":{"created_by":1,"id":"47331","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47331"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047331","sets":["1"]},"author_link":["473590","473594","473598","473604","473596","473599","473602","473589","473605","473588","473595","473603","473601","473591","473597","473592","473600","473593"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"675","bibliographicPageStart":"667","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"The International Journal of Neuropsychopharmacology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effects of antipsychotic drugs have generally been considered to be mediated by blockade of dopamine D2 receptors. The concept of limbic and cortical selectivity of second-generation antipsychotics, i.e. higher dopamine D2 receptor occupancy in the cerebral cortices than in the striatum, has been suggested to explain their clinical efficacy with lower incidence of extrapyramidal side-effects. In this study, regional distribution of dopamine D2 receptor occupancy by risperidone was determined in order to elucidate the limbic and cortical selectivity of second-generation antipsychotics. Striatal and extrastriatal dopamine D2 receptor binding at baseline and after oral administration of 2 mg risperidone were measured in ten healthy men by positron emission tomography (PET) using different tracers with different affinity for the receptors, [11C]raclopride and [11C]FLB 457, respectively. Striatal and extrastriatal occupancies of dopamine D2 receptors were calculated for each brain region. Occupancies of dopamine D2 receptors were about 70% and 60% in the striatum and extrastriatum, respectively. A simulation study showed that non-negligible specific binding in the reference region (cerebellum), could cause systemic underestimation of occupancy in [11C]FLB 457 PET studies, indicating that occupancies in both the striatum and extrastriatum may not have differed. Among the extrastriatal regions including limbic and neocortical regions, no significant regional differences in dopamine D2 receptor occupancy were observed. Thus, limbic and cortical selectivity was not observed by one of the second-generation antipsychotics, risperidone.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1461-1457","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"473588","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arakawa, Ryosuke"}],"nameIdentifiers":[{"nameIdentifier":"473589","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Hidehiko"}],"nameIdentifiers":[{"nameIdentifier":"473590","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takano, Harumasa"}],"nameIdentifiers":[{"nameIdentifier":"473591","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okumura, Masaki"}],"nameIdentifiers":[{"nameIdentifier":"473592","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Otsuka, Tatsui"}],"nameIdentifiers":[{"nameIdentifier":"473593","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikoma, Yoko"}],"nameIdentifiers":[{"nameIdentifier":"473594","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shidahara, Miho"}],"nameIdentifiers":[{"nameIdentifier":"473595","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"473596","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473597","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒川 亮介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473598","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 英彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473599","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473600","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"奥村 正紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473601","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大塚 達以","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473602","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生駒 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473603","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"志田原 美保","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473604","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473605","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"No regional difference in dopamine D2 receptor occupancy by  the second-generation antipsychotic drug risperidone in humans: a positron emission tomography study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"No regional difference in dopamine D2 receptor occupancy by  the second-generation antipsychotic drug risperidone in humans: a positron emission tomography study"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-13"},"publish_date":"2015-11-13","publish_status":"0","recid":"47331","relation_version_is_last":true,"title":["No regional difference in dopamine D2 receptor occupancy by  the second-generation antipsychotic drug risperidone in humans: a positron emission tomography study"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:41:04.219110+00:00"}