{"created":"2023-05-15T14:36:44.311671+00:00","id":47330,"links":{},"metadata":{"_buckets":{"deposit":"bf869848-4251-44eb-8674-0170240443a9"},"_deposit":{"created_by":1,"id":"47330","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47330"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047330","sets":["1"]},"author_link":["473575","473577","473571","473570","473582","473584","473566","473579","473573","473576","473583","473585","473572","473581","473587","473567","473578","473586","473568","473574","473580","473569"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"586","bibliographicPageStart":"578","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"NeuroImage"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In positron emission tomography (PET) studies with radioligands for neuroreceptors, tracer kinetics have\nbeen described by the standard two-tissue compartment model that includes the compartments of\nnondisplaceable binding and specific binding to receptors. In the present study, we have developed a new\ngraphic plot analysis to determine the total distribution volume (VT) and nondisplaceable distribution\nvolume (VND) independently, and therefore the binding potential (BPND). In this plot, Y(t) is the ratio of brain\ntissue activity to time-integrated arterial input function, and X(t) is the ratio of time-integrated brain tissue\nactivity to time-integrated arterial input function. The x-intercept of linear regression of the plots for early\nphase represents VND, and the x-intercept of linear regression of the plots for delayed phase after the\nequilibrium time represents VT. BPND can be calculated by BPND=VT/VND−1. Dynamic PET scanning with\nmeasurement of arterial input function was performed on six healthy men after intravenous rapid bolus\ninjection of [11C]FLB457. The plot yielded a curve in regions with specific binding while it yielded a straight\nline through all plot data in regions with no specific binding. VND, VT, and BPND values calculated by the\npresent method were in good agreement with those by conventional non-linear least-squares fitting\nprocedure. This method can be used to distinguish graphically whether the radioligand binding includes\nspecific binding or not.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1053-8119","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"473566","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokoi, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"473567","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikoma, Yoko"}],"nameIdentifiers":[{"nameIdentifier":"473568","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shidahara, Miho"}],"nameIdentifiers":[{"nameIdentifier":"473569","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seki, Chie"}],"nameIdentifiers":[{"nameIdentifier":"473570","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naganawa, Mika"}],"nameIdentifiers":[{"nameIdentifier":"473571","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Hidehiko"}],"nameIdentifiers":[{"nameIdentifier":"473572","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takano, Harumasa"}],"nameIdentifiers":[{"nameIdentifier":"473573","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yuichi"}],"nameIdentifiers":[{"nameIdentifier":"473574","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichise, Masanori"}],"nameIdentifiers":[{"nameIdentifier":"473575","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"473576","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473577","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"横井 孝司","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473578","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生駒 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473579","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"志田原 美保","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473580","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関 千江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473581","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長縄 美香","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473582","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 英彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473583","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473584","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 裕一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473585","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"市瀬 正則","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473586","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473587","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A new graphic plot analysis for determination of neuroreceptor binding in positron emission tomography studies","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A new graphic plot analysis for determination of neuroreceptor binding in positron emission tomography studies"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-13"},"publish_date":"2015-11-13","publish_status":"0","recid":"47330","relation_version_is_last":true,"title":["A new graphic plot analysis for determination of neuroreceptor binding in positron emission tomography studies"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:41:04.954671+00:00"}