@article{oai:repo.qst.go.jp:00047329,
 author = {Shidahara, Miho and Ito, Hiroshi and Otsuka, Tatsui and Ikoma, Yoko and Arakawa, Ryosuke and Kodaka, Fumitoshi and Seki, Chie and Takano, Harumasa and Takahashi, Hidehiko and E., Turkheimer Federico and Kimura, Yuichi and Kanno, Iwao and Suhara, Tetsuya and 志田原 美保 and 伊藤 浩 and 大塚 達以 and 生駒 洋子 and 荒川 亮介 and 小高 文聰 and 関 千江 and 高野 晴成 and 高橋 英彦 and 木村 裕一 and 菅野 巖 and 須原 哲也},
 issue = {1},
 journal = {Journal of Cerebral Blood Flow and Metabolism},
 month = {Sep},
 note = {The purpose of this study is to investigate errors in quantitative analysis for estimating dopamine D(2) receptor occupancy of antipsychotics with agonist radioligand [(11)C]MNPA by numerical simulation, with particular attention to the validity of a quantitative approach based on the use of a reference region. Synthetic data were validated using clinical data combined with a bootstrap approach. Time-activity curves (TACs) of [(11)C]MNPA were simulated, and the reliability of binding potential (BP(ND)) and occupancy estimated by nonlinear least square (NLS) fitting and a simplified reference tissue model (SRTM) were investigated for various noise levels and scan durations. In the human positron emission tomography (PET) study with and without antipsychotic, risperidone, the uncertainty of BP(ND) and occupancy estimated by SRTM was investigated using resampled TACs based on bootstrap approach with weighted residual errors of fitting. For both NLS and SRTM, it was possible to have <3% of bias in occupancy estimates of [(11)C]MNPA by 60 mins. However, shortened scan duration degrades the quantification of very small binding potentials, especially in case of SRTM. Observations were replicated on the clinical data. Results showed that dopamine D(2) receptor occupancy by antipsychotics can be estimated precisely in region of interest analysis by SRTM with a longer than 60-min [(11)C]MNPA PET scan duration.},
 pages = {187--195},
 title = {Measurement error analysis for the determination of dopamine D2 receptor occupancy using agonist radioligand [11C]MNPA},
 volume = {30},
 year = {2009}
}