@article{oai:repo.qst.go.jp:00047328,
 author = {Seki, Chie and Ito, Hiroshi and Ichimiya, Tetsuya and Arakawa, Ryosuke and Ikoma, Yoko and Shidahara, Miho and Maeda, Jun and Takano, Akihiro and Takahashi, Hidehiko and Kimura, Yuichi and Suzuki, Kazutoshi and Kanno, Iwao and Suhara, Tetsuya and 関 千江 and 伊藤 浩 and 一宮 哲哉 and 荒川 亮介 and 生駒 洋子 and 志田原 美保 and 前田 純 and 高野 晶寛 and 高橋 英彦 and 木村 裕一 and 鈴木 和年 and 菅野 巖 and 須原 哲也},
 issue = {4},
 journal = {Annals of Nuclear Medicine},
 month = {Apr},
 note = {OBJECTIVE: Dopamine transporter (DAT) is a reuptake carrier of dopamine at presynapse that regulates dopaminergic neural transmission. [(11)C]PE2I is a cocaine analog developed as a potent positron emission tomography (PET) ligand for DAT with high selectivity. The aim of this study was to evaluate the applicability of quantification methods using reference tissue models for [(11)C]PE2I. METHODS: Dynamic PET scans were performed in 6 young healthy male volunteers after an intravenous bolus injection of [(11)C]PE2I. Metabolite-corrected arterial plasma-input functions were obtained. Compartment model analysis and plasma-input Logan analysis were performed to determine the kinetic parameters and distribution volume (V (T)). The distribution volume ratio (DVR) was calculated as the ratio of V (T) in the cerebral region to that in the cerebellum. DVRs were also determined by the original multilinear reference tissue model method (MRTMo) and the simplified reference tissue model method (SRTM), comparing the results with those obtained from graphical analysis using arterial input function. To estimate errors in DVR calculated using the reference tissue model, a simulation study that focused on cerebellar kinetics and scan duration was performed. RESULTS: The highest [(11)C]PE2I binding was observed in the striatum, followed by the midbrain and thalamus. The 2-tissue model was preferable to the 1-tissue model for describing the [(11)C]PE2I kinetics in the cerebellum. Both the measured and 90-min simulated data showed that reference tissue models caused an underestimation of DVR in the striatum. The simulation showed that 90-min scan duration was insufficient when cerebellar kinetics was described as a 1-tissue model. Nevertheless, DVR values determined by MRTMo and SRTM were in good agreement with those by the graphical approach in other lower binding regions. CONCLUSION: Due to the [(11)C]PE2I kinetics in the cerebellum and limited scan duration for (11)C, MRTMo and SRTM underestimated the striatal DVR. Despite this limitation, the present study demonstrated the applicability of reference tissue models. Since DAT in the midbrain and thalamus is of interest in the pathophysiology of neuropsychiatric disease, this noninvasive quantitative analysis will be useful for clinical investigations.},
 pages = {249--260},
 title = {Quantitative analysis of dopamine transporters in human brain using [11C]PE2I and positron emission tomography: evaluation of reference tissue models},
 volume = {24},
 year = {2010}
}