{"created":"2023-05-15T14:36:43.955086+00:00","id":47322,"links":{},"metadata":{"_buckets":{"deposit":"8b0d4d70-7a80-481f-8523-5f20223e1e03"},"_deposit":{"created_by":1,"id":"47322","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47322"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047322","sets":["1"]},"author_link":["473384","473388","473383","473393","473389","473398","473401","473394","473395","473397","473391","473404","473387","473400","473403","473385","473402","473399","473392","473390","473396","473386"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"Journal of Cerebral Blood Flow &  Metabolism"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Because of its role in multiple central nervous system\n(CNS) pathways, metabotropic glutamate receptor type 1\n(mGluR1) is a crucial target in the development of\npharmaceuticals for CNS disorders. N-[4-[6-\n(isopropylamino)-pyrimidin-4-yl]-1,3-thiazol-2-yl]-Nmethyl-\n4-[11C]-methylbenzamide ([11C]ITDM) was\nrecently developed as a positron emission tomography\n(PET) ligand for mGluR1. To devise a method for\nmeasurement of the binding potential (BPND) of\n[11C]ITDM to mGluR1, reference tissue methods aimed at\nreplacing measurement of the arterial input function are　desirable. In this study, we evaluated a noninvasive\nquantification method of mGluR1 with [11C]ITDM,\ndemonstrating its accuracy using Huntington disease\nmodel R6/2 mice. The BPND measurements based on the\nLogan reference (Logan Ref) method have closely\napproximated that based on the arterial input method. We\nperformed PET analysis with Logan Ref to assess its\naccuracy in quantifying the decline of mGluR1 expression\nin R6/2 mice. Significant decreases in BPND values in R6/2\nmice were detected in cerebellum, thalamus, striatum,\nand cingulate cortex. We compared autoradiographs of\nR6/2 mouse brain sections with immunohistochemical\nimages, and found a close correlation between changes in\nradioactive signal intensity and degree of mGluR1\nexpression. In conclusion, [11C]ITDM-PET is a promising\ntool for in vivo quantification of mGluR1 expression.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing  Group"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"doi: 10.1038/jcbfm.2013.243","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0271-678X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamasaki, Tomoteru"}],"nameIdentifiers":[{"nameIdentifier":"473383","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujinaga, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"473384","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yui, Joji"}],"nameIdentifiers":[{"nameIdentifier":"473385","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikoma, Yoko"}],"nameIdentifiers":[{"nameIdentifier":"473386","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hatori, Akiko"}],"nameIdentifiers":[{"nameIdentifier":"473387","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Xie, Lin"}],"nameIdentifiers":[{"nameIdentifier":"473388","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakizaka, Hidekatsu"}],"nameIdentifiers":[{"nameIdentifier":"473389","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kumata, Katsushi"}],"nameIdentifiers":[{"nameIdentifier":"473390","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nengaki, Nobuki"}],"nameIdentifiers":[{"nameIdentifier":"473391","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawamura, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"473392","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"473393","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473394","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473395","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473396","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生駒 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473397","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473398","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝 琳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473399","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473400","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473401","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣 信樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473402","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473403","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473404","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Noninvasive quantification of metabotropic glutamate receptortype 1 with [11C]ITDM:a small-animal PET study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Noninvasive quantification of metabotropic glutamate receptortype 1 with [11C]ITDM:a small-animal PET study"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-13"},"publish_date":"2015-11-13","publish_status":"0","recid":"47322","relation_version_is_last":true,"title":["Noninvasive quantification of metabotropic glutamate receptortype 1 with [11C]ITDM:a small-animal PET study"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:41:10.015206+00:00"}