@article{oai:repo.qst.go.jp:00047322,
 author = {Yamasaki, Tomoteru and Fujinaga, Masayuki and Yui, Joji and Ikoma, Yoko and Hatori, Akiko and Xie, Lin and Wakizaka, Hidekatsu and Kumata, Katsushi and Nengaki, Nobuki and Kawamura, Kazunori and Zhang, Ming-Rong and 山崎 友照 and 藤永 雅之 and 由井 譲二 and 生駒 洋子 and 羽鳥 晶子 and 謝 琳 and 脇坂 秀克 and 熊田 勝志 and 念垣 信樹 and 河村 和紀 and 張 明栄},
 issue = {1},
 journal = {Journal of Cerebral Blood Flow &  Metabolism},
 month = {Jan},
 note = {Because of its role in multiple central nervous system
(CNS) pathways, metabotropic glutamate receptor type 1
(mGluR1) is a crucial target in the development of
pharmaceuticals for CNS disorders. N-[4-[6-
(isopropylamino)-pyrimidin-4-yl]-1,3-thiazol-2-yl]-Nmethyl-
4-[11C]-methylbenzamide ([11C]ITDM) was
recently developed as a positron emission tomography
(PET) ligand for mGluR1. To devise a method for
measurement of the binding potential (BPND) of
[11C]ITDM to mGluR1, reference tissue methods aimed at
replacing measurement of the arterial input function are　desirable. In this study, we evaluated a noninvasive
quantification method of mGluR1 with [11C]ITDM,
demonstrating its accuracy using Huntington disease
model R6/2 mice. The BPND measurements based on the
Logan reference (Logan Ref) method have closely
approximated that based on the arterial input method. We
performed PET analysis with Logan Ref to assess its
accuracy in quantifying the decline of mGluR1 expression
in R6/2 mice. Significant decreases in BPND values in R6/2
mice were detected in cerebellum, thalamus, striatum,
and cingulate cortex. We compared autoradiographs of
R6/2 mouse brain sections with immunohistochemical
images, and found a close correlation between changes in
radioactive signal intensity and degree of mGluR1
expression. In conclusion, [11C]ITDM-PET is a promising
tool for in vivo quantification of mGluR1 expression.},
 pages = {1--7},
 title = {Noninvasive quantification of metabotropic glutamate receptortype 1 with [11C]ITDM:a small-animal PET study},
 volume = {34},
 year = {2014}
}