{"created":"2023-05-15T14:36:43.599515+00:00","id":47314,"links":{},"metadata":{"_buckets":{"deposit":"673d1084-5941-433a-9532-5257765c59a0"},"_deposit":{"created_by":1,"id":"47314","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47314"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047314","sets":["1"]},"author_link":["473319","473317","473315","473313","473316","473314","473318","473311","473312"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"e86679","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"PLoS ONE (Online only:URL:http://www.plosone.org)"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aldolase C (Aldoc, also known as ‘‘zebrin II’’), a brain type isozyme of a glycolysis enzyme, is expressed heterogeneously in\nsubpopulations of cerebellar Purkinje cells (PCs) that are arranged longitudinally in a complex striped pattern in the\ncerebellar cortex, a pattern which is closely related to the topography of input and output axonal projections. Here, we\ngenerated knock-in Aldoc-Venus mice in which Aldoc expression is visualized by expression of a fluorescent protein, Venus.\nSince there was no obvious phenotypes in general brain morphology and in the striped pattern of the cerebellum in\nmutants, we made detailed observation of Aldoc expression pattern in the nervous system by using Venus expression in\nAldoc-Venus heterozygotes. High levels of Venus expression were observed in cerebellar PCs, cartwheel cells in the dorsal\ncochlear nucleus, sensory epithelium of the inner ear and in all major types of retinal cells, while moderate levels of Venus\nexpression were observed in astrocytes and satellite cells in the dorsal root ganglion. The striped arrangement of PCs that\nexpress Venus to different degrees was carefully traced with serial section alignment analysis and mapped on the unfolded\nscheme of the entire cerebellar cortex to re-identify all individual Aldoc stripes. A longitudinally striped boundary of Aldoc\nexpression was first identified in the mouse flocculus, and was correlated with the climbing fiber projection pattern and\nexpression of another compartmental marker molecule, heat shock protein 25 (HSP25). As in the rat, the cerebellar nuclei\nwere divided into the rostrodorsal negative and the caudoventral positive portions by distinct projections of Aldoc-positive\nand negative PC axons in the mouse. Identification of the cerebellar Aldoc stripes in this study, as indicated in sample\ncoronal and horizontal sections as well as in sample surface photos of whole-mount preparations, can be referred to in\nfuture experiments","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"24475166","subitem_relation_type_select":"PMID"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujita, Hirofumi"}],"nameIdentifiers":[{"nameIdentifier":"473311","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Hanako"}],"nameIdentifiers":[{"nameIdentifier":"473312","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ajioka, Itsuki"}],"nameIdentifiers":[{"nameIdentifier":"473313","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamazaki, Maya"}],"nameIdentifiers":[{"nameIdentifier":"473314","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Abe, Manabu"}],"nameIdentifiers":[{"nameIdentifier":"473315","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oh-Nishi, Arata"}],"nameIdentifiers":[{"nameIdentifier":"473316","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakimura, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"473317","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugihara, Izumi"}],"nameIdentifiers":[{"nameIdentifier":"473318","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大西 新","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"473319","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Detailed Expression Pattern of Aldolase C (Aldoc) in the Cerebellum, Retina and Other Areas of the CNS Studied in Aldoc-Venus Knock-In Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Detailed Expression Pattern of Aldolase C (Aldoc) in the Cerebellum, Retina and Other Areas of the CNS Studied in Aldoc-Venus Knock-In Mice"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-10-21"},"publish_date":"2015-10-21","publish_status":"0","recid":"47314","relation_version_is_last":true,"title":["Detailed Expression Pattern of Aldolase C (Aldoc) in the Cerebellum, Retina and Other Areas of the CNS Studied in Aldoc-Venus Knock-In Mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:41:15.746032+00:00"}