{"created":"2023-05-15T14:36:41.307671+00:00","id":47262,"links":{},"metadata":{"_buckets":{"deposit":"c8e8c53a-887d-4baf-a4ba-a2a7942336d6"},"_deposit":{"created_by":1,"id":"47262","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47262"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047262","sets":["1"]},"author_link":["472704","472698","472701","472703","472705","472699","472700","472706","472697","472702"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1/2","bibliographicPageEnd":"39","bibliographicPageStart":"30","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"Tissue Engineering. Part A"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The objective of this study was to design and prepare a new contrast agent of magnetic resonance (MR) imaging for the evaluation of therapeutic angiogenesis. Diethylenetriaminepentaacetic acid (DTPA) residue of a chelator was chemically introduced to dextran with a molecular weight of 74,000 (dextran-DTPA). Cyclic peptide containing an arginine-glycine-aspartic acid (RGD) sequence (cyclic RGD) with an inherent affinity for the a(v)B(3) integrin was then introduced to dextran-DTPA (Cyclic RGD-dextran-DTPA). Gd(3+) was added to cyclic RGD-dextran-DTPA to prepare a dextran-based MR contrast agent (Cyclic RGD-dextran-DTPA-Gd). Cyclic RGD-dextran-DTPA-Gd had affinity for cells expressing the a(v)B(3) integrin and showed a higher longitudinal relaxivity compared with DTPA-Gd of an MR contrast agent clinically used. Right femoral, external iliac, and deep femoral and circumflex arteries and veins were surgically ligated to prepare a mouse model of hindlimb ischemia. A laser Doppler analysis and histological evaluation confirmed that hindlimb ischemia healed naturally and was accompanied by angiogenesis, while a(v)B(3) integrin was expressed in the ischemic-angiogenic region without any treatment. Mice at 7 days after vascular ligation were used as an angiogenesis model. When intravenously injected into mice with hindlimb ischemia, cyclic RGD-dextran-DTPA accumulated in the ischemic-angiogenic region and showed the MR ability to detect the ischemic-angiogenic region. It is concluded that cyclic RGD-dextran-DTPA-Gd is a promising material for evaluation of therapeutic angiogenesis.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1089/ten.tea.2012.0131","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1937-3341","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Jo, Jun-ichiro"}],"nameIdentifiers":[{"nameIdentifier":"472697","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakahara, Teppei"}],"nameIdentifiers":[{"nameIdentifier":"472698","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"472699","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"472700","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tabata, Yasuhiko"}],"nameIdentifiers":[{"nameIdentifier":"472701","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"472702","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"城 潤一郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"472703","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中原 鉄平","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"472704","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"472705","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"472706","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Preparation of polymer-based magnetic resonance imaging contrast agent to visualize therapeutic angiogenesis.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Preparation of polymer-based magnetic resonance imaging contrast agent to visualize therapeutic angiogenesis."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-08-19"},"publish_date":"2015-08-19","publish_status":"0","recid":"47262","relation_version_is_last":true,"title":["Preparation of polymer-based magnetic resonance imaging contrast agent to visualize therapeutic angiogenesis."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:41:57.905018+00:00"}