{"created":"2023-05-15T14:36:41.092344+00:00","id":47257,"links":{},"metadata":{"_buckets":{"deposit":"04a2d91e-e8a4-4ed6-a0b5-26a049d7b749"},"_deposit":{"created_by":1,"id":"47257","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47257"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047257","sets":["1"]},"author_link":["472648","472650","472651","472649","472652"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"282","bibliographicPageStart":"277","bibliographicVolumeNumber":"55","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The influence of a host defense protein, lactoferrin (LF), contained in exocrine secretions such as milk, on radiation disorder was investigated. A total of 25 C3H/He mice in each of two groups were maintained with 0.1% LF-added and LF-free diets, respectively, for one month. The mice were then treated with single whole-body X-ray irradiation at a sublethal dose (6.8 Gy), and the survival rate after irradiation was investigated. The survival rate at 30 d after irradiation was relatively higher in the LF group than in the control group (LF-free), (85 and 62%, respectively). The body weight 15 d after X-ray irradiation was also significantly greater in the LF group than in the control group. The hemoglobin level and hematocrit value were higher in the LF group at 5 d before X-ray irradiation. Another 52 mice underwent whole-body X-ray irradiation at the sublethal dose (6.8 Gy), and then LF was intraperitoneally injected once at 4 mg/animal to half of them. The survival rate in LF-treated mice 30 d after irradiation was 92%, significantly higher than in mice treated with saline (50%) (P = 0.0012). In addition, LF showed hydroxyl radical scavenger activity in vitro. These findings suggest that LF may inhibit radiation damage. ","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"oxford university press"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nishimura, Yoshikazu"}],"nameIdentifiers":[{"nameIdentifier":"472648","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Homma-Takeda, Shino"}],"nameIdentifiers":[{"nameIdentifier":"472649","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kim, Hee-Sun"}],"nameIdentifiers":[{"nameIdentifier":"472650","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakuta, Izuru"}],"nameIdentifiers":[{"nameIdentifier":"472651","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武田 志乃","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"472652","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Radioprotection of mice by lactoferrin against irradiated with sublethal X-rays.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Radioprotection of mice by lactoferrin against irradiated with sublethal X-rays."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-08-17"},"publish_date":"2015-08-17","publish_status":"0","recid":"47257","relation_version_is_last":true,"title":["Radioprotection of mice by lactoferrin against irradiated with sublethal X-rays."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:42:00.757682+00:00"}