@article{oai:repo.qst.go.jp:00047257,
 author = {Nishimura, Yoshikazu and Homma-Takeda, Shino and Kim, Hee-Sun and Kakuta, Izuru and 武田 志乃},
 issue = {2},
 journal = {Journal of Radiation Research},
 month = {Feb},
 note = {The influence of a host defense protein, lactoferrin (LF), contained in exocrine secretions such as milk, on radiation disorder was investigated. A total of 25 C3H/He mice in each of two groups were maintained with 0.1% LF-added and LF-free diets, respectively, for one month. The mice were then treated with single whole-body X-ray irradiation at a sublethal dose (6.8 Gy), and the survival rate after irradiation was investigated. The survival rate at 30 d after irradiation was relatively higher in the LF group than in the control group (LF-free), (85 and 62%, respectively). The body weight 15 d after X-ray irradiation was also significantly greater in the LF group than in the control group. The hemoglobin level and hematocrit value were higher in the LF group at 5 d before X-ray irradiation. Another 52 mice underwent whole-body X-ray irradiation at the sublethal dose (6.8 Gy), and then LF was intraperitoneally injected once at 4 mg/animal to half of them. The survival rate in LF-treated mice 30 d after irradiation was 92%, significantly higher than in mice treated with saline (50%) (P = 0.0012). In addition, LF showed hydroxyl radical scavenger activity in vitro. These findings suggest that LF may inhibit radiation damage.},
 pages = {277--282},
 title = {Radioprotection of mice by lactoferrin against irradiated with sublethal X-rays.},
 volume = {55},
 year = {2014}
}