@article{oai:repo.qst.go.jp:00047226, author = {Takahashi, Hidehiko and Takano, Harumasa and F., Camerer Colin and Ideno, Takashi and Okubo, Shigetaka and Matsui, Hiroshi and Tamari, Yuki and Takemura, Kazuhisa and Arakawa, Ryosuke and Kodaka, Fumitoshi and Yamada, Makiko and Eguchi, Yoko and Murai, Toshiya and Okubo, Yoshiro and Kato, Motoichiro and Ito, Hiroshi and Suhara, Tetsuya and 高橋 英彦 and 高野 晴成 and 松井 博史 and 荒川 亮介 and 小高 文聰 and 山田 真希子 and 江口 洋子 and 大久保 善朗 and 加藤 元一郎 and 伊藤 浩 and 須原 哲也}, issue = {11}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, month = {Mar}, note = {How does one deal with unfair behaviors? This subject has long been investigated by various disciplines including philosophy, psychology, economics, and biology. However, our reactions to unfairness differ from one individual to another. Experimental economics studies using the ultimatum game (UG), in which players must decide whether to accept or reject fair or unfair offers, have also shown that there are substantial individual differences in reaction to unfairness. However, little is known about psychological as well as neurobiological mechanisms of this observation. We combined a molecular imaging technique, an economics game, and a personality inventory to elucidate the neurobiological mechanism of heterogeneous reactions to unfairness. Contrary to the common belief that aggressive personalities (impulsivity or hostility) are related to the high rejection rate of unfair offers in UG, we found that individuals with apparently peaceful personalities (straightforwardness and trust) rejected more often and were engaged in personally costly forms of retaliation. Furthermore, individuals with a low level of serotonin transporters in the dorsal raphe nucleus (DRN) are honest and trustful, and thus cannot tolerate unfairness, being candid in expressing their frustrations. In other words, higher central serotonin transmission might allow us to behave adroitly and opportunistically, being good at playing games while pursuing self-interest. We provide unique neurobiological evidence to account for individual differences of reaction to unfairness.}, pages = {4281--4284}, title = {Honesty mediates the relationship between serotonin and reaction to unfairness}, volume = {109}, year = {2012} }