@article{oai:repo.qst.go.jp:00047199,
 author = {Shimada, Hitoshi and Shinoto, Hitoshi and Hirano, Shigeki and Fukushi, Kiyoshi and Irie, Toshiaki and Ito, Hiroshi and Higuchi, Makoto and Suhara, Tetsuya and et.al and 島田 斉 and 篠遠 仁 and 平野 成樹 and 福士 清 and 入江 俊章 and 伊藤 浩 and 樋口 真人 and 須原 哲也},
 issue = {2},
 journal = {Movement Disorders},
 month = {Dec},
 note = {The aim of this study was to investigate whether amyloid deposition is associated with Alzheimer's disease (AD)-like cortical atrophy in Lewy body (LB) disease (LBD). Participants included 15 LBD with dementia patients (8 with dementia with Lewy bodies [DLB] and 7 with Parkinson's disease [PD] with dementia [PDD]), 13 AD patients, and 17 healthy controls. Age, gender, and Mini–Mental State Examination scores were matched between patient groups. All subjects underwent PET scans with [11C]Pittsburgh Compound B to measure brain amyloid deposition as well as three-dimensional T1-weighted MRI. Gray-matter volumes (GMVs) were estimated by voxel-based morphometry. Volumes-of-interest analyses were also performed. Forty percent of the 15 DLB/PDD patients were amyloid positive, whereas all AD patients and none of the healthy controls were amyloid positive. Amyloid-positive DLB/PDD and AD patients showed very similar patterns of cortical atrophy in the parahippocampal area and lateral temporal and parietal cortices, with 95.2% of cortical atrophy distribution being overlapped. In contrast, amyloid-negative DLB/PDD patients had no significant cortical atrophy. Compared to healthy controls, parahippocampal GMVs were reduced by 26% in both the amyloid-positive DLB/PDD and AD groups and by 10% in the amyloid-negative DLB/PDD group. The results suggest that amyloid deposition is associated with AD-like atrophy in DLB/PDD patients. Early intervention against amyloid may prevent or delay AD-like atrophy in DLB/PDD patients with amyloid deposition.},
 pages = {169--175},
 title = {Beta-Amyloid in Lewy body disease is related to Alzheimer's disease-like atrophy},
 volume = {28},
 year = {2012}
}