{"created":"2023-05-15T14:36:34.575067+00:00","id":47109,"links":{},"metadata":{"_buckets":{"deposit":"7d9493dd-cf3e-4ecd-9dad-fbf60c54838b"},"_deposit":{"created_by":1,"id":"47109","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47109"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047109","sets":["1"]},"author_link":["470668","470670","470665","470664","470666","470667","470669","470671"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"631","bibliographicPageStart":"626","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"Macromolecular bioscience"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Although the use of small interfering RNA (siRNA) is a promising technique for gene regulation, spatiotemporal control of the effects of siRNA must be achieved if the technique is to be safe and practical. Here, a method for spatiotemporal regulation of genes with nanoparticles containing siRNA is reported. The siRNA is encapsulated in photodegradable nanoparticles that are internalized to SKOV3-Luc cells, where the siRNA is released from the nanoparticles by UV irradiation for 30 s. The encapsulated siRNA only shows no gene-silencing effects, but release of the siRNA upon UV radiation leads to sequence-specific silencing of the luciferase gene in the cells. These results indicate that photodegradable siRNA-containing nanoparticles can be useful for time- and space-dependent regulation of gene expression in cells.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"24510781","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/mabi.201300393","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1616-5187","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Murayama, Shuhei"}],"nameIdentifiers":[{"nameIdentifier":"470664","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kos, Petra"}],"nameIdentifiers":[{"nameIdentifier":"470665","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyata, Kanjiro"}],"nameIdentifiers":[{"nameIdentifier":"470666","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kataoka, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"470667","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wagner, Ernst"}],"nameIdentifiers":[{"nameIdentifier":"470668","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Masaru"}],"nameIdentifiers":[{"nameIdentifier":"470669","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村山 周平","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470670","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 大","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470671","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Gene regulation by intracellular delivery and photodegradation of nanoparticles containing small interfering RNA.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Gene regulation by intracellular delivery and photodegradation of nanoparticles containing small interfering RNA."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-04-27"},"publish_date":"2015-04-27","publish_status":"0","recid":"47109","relation_version_is_last":true,"title":["Gene regulation by intracellular delivery and photodegradation of nanoparticles containing small interfering RNA."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:43:47.556535+00:00"}