@article{oai:repo.qst.go.jp:00047106, author = {Suzuki, Chie and B, Tsuji Atsushi and Kato, Koichi and Kikuchi, Tatsuya and Sudo, Hitomi and Okada, Maki and Sugyo, Aya and Zhang, Ming-Rong and Arano, Yasushi and Saga, Tsuneo and 鈴木 千恵 and 辻 厚至 and 加藤 孝一 and 菊池 達矢 and 須藤 仁美 and 岡田 真希 and 須尭 綾 and 張 明栄 and 荒野 泰 and 佐賀 恒夫}, issue = {10}, journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine}, month = {Oct}, note = {Preoperative noninvasive imaging to estimate the quantity and spatial distribution of protoporphyrin IX (PpIX) accumulation in tumors induced by 5-aminolevulinic acid (ALA) administration is expected to improve the efficacy of ALA-based fluorescence-guided resection and photo- and sonodynamic therapies. PpIX synthesis from exogenous ALA has been reported to be regulated by ALA influx or ALA dehydratase (ALAD) activity, which catalyzes the first step of the synthesis. In this study, we characterized the properties of a (11)C-labeled ALA analog, 5-amino-4-oxo-[6-(11)C]hexanoic acid ((11)C-MALA), as a PET tracer to estimate PpIX accumulation.}, pages = {1671--1677}, title = {Preclinical Characterization of 5-Amino-4-Oxo-[6-11C]Hexanoic Acid as an Imaging Probe to Estimate Protoporphyrin IX Accumulation Induced by Exogenous Aminolevulinic Acid.}, volume = {55}, year = {2014} }