{"created":"2023-05-15T14:36:33.052352+00:00","id":47076,"links":{},"metadata":{"_buckets":{"deposit":"285b22b2-c92c-4f2a-9b13-ffb5efcf99bc"},"_deposit":{"created_by":1,"id":"47076","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47076"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047076","sets":["1"]},"author_link":["470150","470163","470165","470158","470171","470168","470155","470169","470148","470162","470167","470154","470172","470149","470170","470157","470159","470147","470166","470164","470153","470151","470152","470161","470156","470160"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"412","bibliographicPageStart":"406","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"Nuclear Medicine and Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction: The functions of I2-imidazoline receptors (I2Rs) are unknown, but evidence\nexists for their involvement in various neuropsychiatric disorders. Although a few positron emission\ntomography (PET) I2R ligands have been developed, of which [11C]FTIMD and [11C]BU99008 were\nevaluated as PET I2R imaging ligands in monkeys, no human PET imaging study using an I2R-selective\nPET ligand has been conducted yet. Thus, we synthesized an 18F-labeled I2R-selective ligand\n(BU99018 or FEBU, Ki for I2Rs = 2.6 nM), and evaluated its application using rodents in PET imaging in\nvivo toward the development of a clinically-useful I2R PET imaging ligand.\nMethods: [18F]FEBU was synthesized by the reaction of its precursor and [18F]fluoroethyl bromide. A\nbiodistribution and brain PET study were conducted in mice and rats, respectively.\nResults: [18F]FEBU was successfully synthesized, yielding a radioactivity suitable for injection (10.1 ±\n5.3% at the end of the irradiation (n = 10) based on 18F-). The specific activity at end of synthesis\n(EOS) was 40-147 TBq/mmol (n = 10). The radiochemical purity was >99% at EOS and remained\n>99% for 90 min after EOS. In mice, brain uptake was relatively high. In the blocking study with the coinjection\nof the high-affinity I2R ligand BU224 (1 mg/kg b.w.), brain uptake was significantly decreased\n30 min post-injection. In the PET studies, the radioactivity was highly accumulated in the I2R-rich\nhypothalamus. Pretreatment with BU224 (1 mg/kg b.w.) significantly decreased the radioactivity in\nthe hypothalamus to 23% of that of the control from 60 to 90 min post-injection.\nConclusion: [18F]FEBU was sufficiently stable as a PET ligand and had a relatively high specific binding\naffinity for I2Rs in rats and mice.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawamura, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"470147","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimoda, Yoko"}],"nameIdentifiers":[{"nameIdentifier":"470148","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kumata, Katsushi"}],"nameIdentifiers":[{"nameIdentifier":"470149","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujinaga, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"470150","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yui, Joji"}],"nameIdentifiers":[{"nameIdentifier":"470151","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamasaki, Tomoteru"}],"nameIdentifiers":[{"nameIdentifier":"470152","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Xie, Lin"}],"nameIdentifiers":[{"nameIdentifier":"470153","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hatori, Akiko"}],"nameIdentifiers":[{"nameIdentifier":"470154","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakizaka, Hidekatsu"}],"nameIdentifiers":[{"nameIdentifier":"470155","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yusuke, Kurihara"}],"nameIdentifiers":[{"nameIdentifier":"470156","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, Masanao"}],"nameIdentifiers":[{"nameIdentifier":"470157","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nengaki, Nobuki"}],"nameIdentifiers":[{"nameIdentifier":"470158","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"470159","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470160","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下田 陽子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470161","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊田 勝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470162","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤永 雅之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470163","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470164","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470165","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"謝 琳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470166","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470167","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"脇坂 秀克","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470168","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栗原 雄祐","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470169","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川 政直","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470170","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"念垣 信樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470171","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470172","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"In vivo evaluation of a new 18F-labeled PET ligand, [18F]FEBU, for the imaging of I2-imidazoline receptors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"In vivo evaluation of a new 18F-labeled PET ligand, [18F]FEBU, for the imaging of I2-imidazoline receptors"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-04-07"},"publish_date":"2015-04-07","publish_status":"0","recid":"47076","relation_version_is_last":true,"title":["In vivo evaluation of a new 18F-labeled PET ligand, [18F]FEBU, for the imaging of I2-imidazoline receptors"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:44:12.008945+00:00"}