{"created":"2023-05-15T14:36:32.705239+00:00","id":47068,"links":{},"metadata":{"_buckets":{"deposit":"5202ad30-00d6-4b1b-a414-0be34a2bc812"},"_deposit":{"created_by":1,"id":"47068","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47068"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047068","sets":["1"]},"author_link":["470056","470046","470048","470054","470052","470055","470049","470047","470051","470050","470053","470045"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-02","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"8283-7","bibliographicPageStart":"8283-1","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"SCIENTIFIC REPORTS"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We present a system-wide transcriptional network structure that controls cell types in the context of expression pattern transitions that correspond to cell type transitions. Co-expression based analyses uncovered a system-wide, ladder-like transcription factor cluster structure composed of nearly 1,600 transcription factors in a human transcriptional network. Computer simulations based on a transcriptional regulatory model deduced from the system-wide, ladder-like transcription factor cluster structure reproduced expression pattern transitions when human THP-1 myelomonocytic leukaemia cells cease proliferation and differentiate under phorbol myristate acetate stimulation. The behaviour of MYC, a reprogramming Yamanaka factor that was suggested to be essential for induced pluripotent stem cells during dedifferentiation, could be interpreted based on the transcriptional regulation predicted by the system-wide, ladder-like transcription factor cluster structure. This study introduces a novel system-wide structure to transcriptional networks that provides new insights into network topology.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/srep08283","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.nature.com/srep/2015/150206/srep08283/full/srep08283.html"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.nature.com/srep/2015/150206/srep08283/full/srep08283.html","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakata, Katsumi"}],"nameIdentifiers":[{"nameIdentifier":"470045","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohyanagi, Hajime"}],"nameIdentifiers":[{"nameIdentifier":"470046","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Shinji"}],"nameIdentifiers":[{"nameIdentifier":"470047","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nobori, Hiroya"}],"nameIdentifiers":[{"nameIdentifier":"470048","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hayashi, Akiko"}],"nameIdentifiers":[{"nameIdentifier":"470049","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii, Hideshi"}],"nameIdentifiers":[{"nameIdentifier":"470050","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"O., Daub Carsten"}],"nameIdentifiers":[{"nameIdentifier":"470051","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawai, Jun"}],"nameIdentifiers":[{"nameIdentifier":"470052","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Harukazu"}],"nameIdentifiers":[{"nameIdentifier":"470053","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Toshiyuki"}],"nameIdentifiers":[{"nameIdentifier":"470054","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"林 昭子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470055","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"齋藤 俊行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470056","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"System-wide analysis of the transcriptional network of human myelomonocytic leukemia cells predicts attractor structure and phorbol-ester-induced differentiation and dedifferentiation transitions","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"System-wide analysis of the transcriptional network of human myelomonocytic leukemia cells predicts attractor structure and phorbol-ester-induced differentiation and dedifferentiation transitions"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-25"},"publish_date":"2015-03-25","publish_status":"0","recid":"47068","relation_version_is_last":true,"title":["System-wide analysis of the transcriptional network of human myelomonocytic leukemia cells predicts attractor structure and phorbol-ester-induced differentiation and dedifferentiation transitions"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:44:18.005649+00:00"}