@article{oai:repo.qst.go.jp:00047068,
 author = {Sakata, Katsumi and Ohyanagi, Hajime and Sato, Shinji and Nobori, Hiroya and Hayashi, Akiko and Ishii, Hideshi and O., Daub Carsten and Kawai, Jun and Suzuki, Harukazu and Saito, Toshiyuki and 林 昭子 and 齋藤 俊行},
 journal = {SCIENTIFIC REPORTS},
 month = {Feb},
 note = {We present a system-wide transcriptional network structure that controls cell types in the context of expression pattern transitions that correspond to cell type transitions. Co-expression based analyses uncovered a system-wide, ladder-like transcription factor cluster structure composed of nearly 1,600 transcription factors in a human transcriptional network. Computer simulations based on a transcriptional regulatory model deduced from the system-wide, ladder-like transcription factor cluster structure reproduced expression pattern transitions when human THP-1 myelomonocytic leukaemia cells cease proliferation and differentiate under phorbol myristate acetate stimulation. The behaviour of MYC, a reprogramming Yamanaka factor that was suggested to be essential for induced pluripotent stem cells during dedifferentiation, could be interpreted based on the transcriptional regulation predicted by the system-wide, ladder-like transcription factor cluster structure. This study introduces a novel system-wide structure to transcriptional networks that provides new insights into network topology.},
 pages = {8283-1--8283-7},
 title = {System-wide analysis of the transcriptional network of human myelomonocytic leukemia cells predicts attractor structure and phorbol-ester-induced differentiation and dedifferentiation transitions},
 volume = {5},
 year = {2015}
}