{"created":"2023-05-15T14:36:32.572221+00:00","id":47065,"links":{},"metadata":{"_buckets":{"deposit":"bc6e6ca1-f589-4e9a-afa7-21c61cef4622"},"_deposit":{"created_by":1,"id":"47065","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47065"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047065","sets":["1"]},"author_link":["470001","469998","470006","470009","470002","469999","470004","470000","470008","469997","470010","470003","470007","470011","470005"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-02","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"47","bibliographicPageStart":"43","bibliographicVolumeNumber":"773","bibliographic_titles":[{"bibliographic_title":"Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Tumors are heterogeneous in nature and consist of multiple cell types. Among them, cancer stem-like cells (CSCs) are suggested to be the principal cause of tumor metastasis, resistance and recurrence. Therefore, understanding the behavior of CSCs in direct and indirect irradiations is crucial for clinical radiotherapy. Here, the CSCs and their counterpart non stem-like cancer cells (NSCCs) in human HT1080 fibrosarcoma cell line were sorted and labelled, then the two cell subtypes were mixed together and chosen separately to be irradiated via a proton microbeam. The radiation-induced bystander effect (RIBE) between the CSCs and NSCCs was measured by imaging 53BP1 foci, a widely used indicator for DNA double strand break (DSB). CSCs were found to be less active than NSCCs in both the generation and the response of bystander signals. Moreover, the nitric oxide (NO) scavenger c-PTIO can effectively alleviate the bystander effect in bystander NSCCs but not in bystander CSCs, indicating a difference of the two cell subtypes in NO signal response. To our knowledge, this is the first report shedding light on the RIBE between CSCs and NSCCs, which might contribute to a further understanding of the out-of-field effect in cancer radiotherapy.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Ltd."}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"17316074","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"doi:10.1016/j.mrfmmm.2015.01.012","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.sciencedirect.com/science/article/pii/S0027510715000238"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.sciencedirect.com/science/article/pii/S0027510715000238","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0027-5107","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yu, Liu"}],"nameIdentifiers":[{"nameIdentifier":"469997","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Alisa"}],"nameIdentifiers":[{"nameIdentifier":"469998","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"469999","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fu, Qibin"}],"nameIdentifiers":[{"nameIdentifier":"470000","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oikawa, Masakazu"}],"nameIdentifiers":[{"nameIdentifier":"470001","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yang, Gen"}],"nameIdentifiers":[{"nameIdentifier":"470002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Konishi, Teruaki"}],"nameIdentifiers":[{"nameIdentifier":"470003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uchihori, Yukio"}],"nameIdentifiers":[{"nameIdentifier":"470004","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"K, Hei Tom"}],"nameIdentifiers":[{"nameIdentifier":"470005","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wang, Yugang"}],"nameIdentifiers":[{"nameIdentifier":"470006","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林 亜利紗","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470007","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田 武","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470008","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"及川 将一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470009","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小西 輝昭","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470010","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"内堀 幸夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470011","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Target irradiation induced bystander effects between stem-like and non stem-like cancer cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Target irradiation induced bystander effects between stem-like and non stem-like cancer cells"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-25"},"publish_date":"2015-03-25","publish_status":"0","recid":"47065","relation_version_is_last":true,"title":["Target irradiation induced bystander effects between stem-like and non stem-like cancer cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:44:20.240284+00:00"}