{"created":"2023-05-15T14:36:32.398016+00:00","id":47061,"links":{},"metadata":{"_buckets":{"deposit":"df610518-9672-4d42-9cdc-026f8426b323"},"_deposit":{"created_by":1,"id":"47061","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"47061"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00047061","sets":["1"]},"author_link":["469952","469950","469956","469955","469953","469949","469957","469951","469954","469948"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1124","bibliographicPageStart":"1119","bibliographicVolumeNumber":"90","bibliographic_titles":[{"bibliographic_title":"International Journal of Radiation Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose : To determine the dose-dependent relative \nbiological effectiveness (RBE) for tumor prevalence in mice\nreceiving single localized doses to their right leg of either \ncarbon ions (15, 45 or 75 keV/ μ m) or 137Cs gamma rays.\nMethods and materials : A total of 1647 female C3H mice \nwere irradiated to their hind legs with a localized dose of \neither reference gamma rays or 15, 45 or 75 keV/ μ m \ncarbon-ion beams. Irradiated mice were evaluated for \ntumors twice a month during their three-year life span, and \nthe dimensions of any tumors found were measured with \na caliper. The tumor induction frequency was calculated by\n Kaplan-Meier analysis.\nResults : The incidence of tumors from 50 Gy of 45 \nkeV/ μ m carbon ions was marginally higher than those \nfrom 50 Gy of gamma rays. However, 60 Gy of 15 keV/ μ m \ncarbon ions induced significantly fewer tumors than did \ngamma rays.  RBE values of 0.87± 0.12, 1.29 ± 0.08 or \n2.06 ± 0.39 for lifetime tumorigenesis were calculated for \n15, 45 or 75 keV/ μ m carbon-ion beams, respectively. \nFibrosarcoma predominated, with no Linear Energy \nTransfer (LET)-dependent differences in the tumor \nhistology. Experiments measuring the late effect of leg \nskin shrinkage suggested that the carcinogenic damage \nof 15 keV/ μ m carbon ions would be less than that of \ngamma rays.\nConclusions : We conclude that patients receiving radiation \ndoses to their normal tissues would face less risk of \nsecondary tumor induction by carbon ions of intermediate \nLET values compared to equivalent doses of photons.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"informa healthcare"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0955-3002 print / 1362-3095 online","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ando, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"469948","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koike, Sachiko"}],"nameIdentifiers":[{"nameIdentifier":"469949","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohmachi, Yasushi"}],"nameIdentifiers":[{"nameIdentifier":"469950","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ando, Yutaka"}],"nameIdentifiers":[{"nameIdentifier":"469951","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobashi, Gen"}],"nameIdentifiers":[{"nameIdentifier":"469952","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 興一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"469953","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池 幸子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"469954","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大町 康","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"469955","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 裕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"469956","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小橋 元","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"469957","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Tumor induction in mice after local irradiation with single doses of either carbon-ion beams or gamma rays","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Tumor induction in mice after local irradiation with single doses of either carbon-ion beams or gamma rays"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-03-25"},"publish_date":"2015-03-25","publish_status":"0","recid":"47061","relation_version_is_last":true,"title":["Tumor induction in mice after local irradiation with single doses of either carbon-ion beams or gamma rays"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:44:23.047179+00:00"}